HEPATOPROTECTIVE ACTIVITY OF ETHYL ACETATE EXTRACT OF ADHATODA VASICA IN SWISS ALBINO RATS

Rayese Ahmad; Vaseem Raja; Manik Sharma

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IJCRR - 5(6), March, 2013

Pages: 16-21

HEPATOPROTECTIVE ACTIVITY OF ETHYL ACETATE EXTRACT OF ADHATODA VASICA IN SWISS ALBINO RATS

Author: Rayese Ahmad, Vaseem Raja, Manik Sharma

Category: Healthcare

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Abstract:

The hepatoprotective activity of Ethyl acetate extract of Adhatoda vasica was investigated against CCl4 induced liver damage in Swiss albino rats. At the dose of 1ml/kg, CCl4 induced liver damage in rats as manifested by statistically significant increase in serum Alanine aminotransferase, (ALT), Aspartate aminotransfrase (AST), Alkaline Phosphatase (ALP) and also in serum Bilirubin. Pre-treatment of rats with the ethyl acetate Extract of Adhatoda Vasica (100mg/kg and 200mg/kg) prior to the CCl4 dose at 1ml/kg statistically lowered the three serum level enzymes and also Bilirubin. Histopathlogical observations also coincided with the above results, however 200mg/kg dose was found to be more active. Current results suggest that Ethyl acetate extract of Adhatoda vasica has potent hepatoprotective effect against CCl4 - induced liver damage.

Keywords: Adhatoda vasica, CCl4, silymarin and DMSO.

Citation:

Rayese Ahmad, Vaseem Raja, Manik Sharma. HEPATOPROTECTIVE ACTIVITY OF ETHYL ACETATE EXTRACT OF ADHATODA VASICA IN SWISS ALBINO RATS International Journal of Current Research and Review. 5(6), March, 16-21

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