IJCRR - 8(23), December, 2016
Pages: 11-15
A STUDY OF THYROID PROFILE AND SERUM ALBUMIN IN PREECLAMPSIA WOMEN
Author: Rahul R. Chaudhary, M.G. Muddeshwar
Category: Healthcare
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Abstract:
Aim: The study was carried out to estimate thyroid profile and serum albumin level in preeclamptic women as compare to normotensive women. In addition to this correlation between thyroid profile and albumin in preeclamptic women was also calculated.
Material and Methods: The study comprised of 60 cases of preeclamptic women who attended in Obstetrics and Gynaecology Department in Govt. Medical College, Nagpur from February 2013 to August 2014 and 60 normotensive healthy womens as controls. Serum total Tri-iodothyronine (T3), Tetraiodothyronine (T4), Thyroid Stimulating Hormone (TSH) and serum albumin were estimated.
Results: We observed that out of 60 preeclampsia patients 13 (21.66%) women having hypothyroidism, 18 (30%) women having sub-hypothyroidism and 29 (48.33%) women were of euthyroid. The mean serum TSH in preeclamptic cases (preeclampsia women) were increased significantly (p >0.001). On the other hand serumT3 levels and Serum T4 levels were decreased significantly in preeclamptic women when compared to controls (p >0.001). Serum albumin was decreased significantly in preeclamptic women when as compared to controls (p >0.001). We found that there was statistically significant positive correlation between serum T3 and T4 and serum albumin (r = 0.8735, p = 0.0001) and statistically significant negative correlation between serum TSH and serum albumin (r = - 0.6109 p = 0.0001).
Conclusion: From the results all these parameters play an important role in preeclampsia hence early detection of these parameters in preeclampsia may help to improve maternal and fetal outcome.
Keywords: T3 -Total triiodothyronine, T4- Tetraiodothyronine, TSH- Thyroid stimulating hormone
Citation:
Rahul R. Chaudhary, M.G. Muddeshwar. A STUDY OF THYROID PROFILE AND SERUM ALBUMIN IN PREECLAMPSIA WOMEN International Journal of Current Research and Review. 8(23), December, 11-15
References:
1. Soma-Pillay P, Nelson-Piercy C; Tolppanen H, Mebazaa A. Physiological changes in pregnancy. Cardiovasc J Afr. 2016;27(2):89-94.
2. Ghosh MK. Maternal Mortality: A Global Perspective. J Reprod Med. 2001;46(5):427-33.
3. World Health Organization. The World Health Report 1998 . Life in the 21st century. 1998. p. 97.
4. Roberts J, Redman C. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet. 1993 Jun;341(8858):1447-51.
5. Rodgers GM, Taylor RN, Roberts JM. Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells. Am J Obstet Gynecol. Elsevier; 1988 Oct 10;159(4):908-14.
6. Goode GK, Miller JP, Heagerty AM. Hyperlipidaemia, hypertension, and coronary heart disease. Lancet. 1995 Feb;345(8946):362-4.
7. Kuang-Yu J, Laszik ZG. Renal Effects of Preeclampsia [Internet]. Available from: www.intechopen.com
8. Stillman IE, Karumanch SA. The Glomerular Injury of Preeclampsia. J Am scocity Nephrol. 2007;18:2281-4.
9. Strevens H, Wide-Swensson D, Hansen A, Horn T, Ingemarsson I, Larsen S, et al. Glomerular endotheliosis in normal pregnancy and pre-eclampsia. An Int J Obstet Gynaecol. 2003 Sep;110(9):831-6.
10. Pasupathi P, Chandrasekar V, Kumar US. Thyroid Hormone Changes in Pregnant and Non-Pregnant Women: A Case-Control Study. Thyroid Sci. 2009;4(3):3-7.
11. Khandakar M, Ali AR, Kahtun M. Thyroid status of normal pregnant women in Dhaka City. Mymensingh Med J. 2002;11(1):1- 5.
12. Qublan HS, Al-Kaisi IJ, Hindawi IM, Hiasat MS, Awamleh I, Hamaideh a. H, et al. Severe pre-eclampsia and maternal thyroid function. J Obstet Gynaecol. 2003 Jan;23(3):244-6.
13. Kaya E, Sahin Y, Ozkceci Z, Pasaoglu H. Relation between birth weight and thyroid function in preeclampsia. Gynecol Obstet Invest. 1994;37(1):30-3.
14. Hubel CA. Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med. 1999;222(3):222–35.
15. Fantz CR, Dagogo-jack S, Ladenson JH, Gronowski AM. Thyroid Function during Pregnancy. Clin Chem. 1999;45(12):2250- 8.
16. Das S, Char D, Sarkar S, Saha TK, Biswas S. Evaluation of Thyroid Hormone Changes in Non-Pregnant , Normotensive Pregnant and Pregnancy with Preeclampsia. J Dent Med Sci. 2013;11(6):16-8.
17. Pasupathi P, Deepa M, Rani P, Vidhya Sankar K, SP satish kumar. Evaluation of Serum Lipids and Thyroid Hormone Changes in Non-Pregnant, Pregnant, and Preeclampsia Women. Thyroid Sci. 2009;4(10):2-7.
18. Khadem N, Ayatollahi H, Roodsari FV, Ayati S, Dalili E, Shahabian M, et al. Comparison of serum levels of Triiodothyronine ( T3 ), Thyroxine ( T4 ), and Thyroid Stimulating Hormone ( TSH ) in preeclampsia and normal pregnancy. Iran J Reprod Med. 2012;10(1):47-52.
19. Kumar A, Ghosh BK, Murthy NS. Maternal thyroid hormonal status in preeclampsia. Indian J Med Sci. 2005;59(2):57-63.
20. Basbug M, Aygen E, Tayyar M, Tutus A, Kaya E, Oktem O. Correlation between maternal thyroid function tests and endothelin in preeclampsia-eclampsia. Obstet Gynecol. 1999;94(4):551-5.
21. Khaliq F, Singhal U, Arshad Z, Hossain MM. Thyroid functions in pre-eclampsia and its correlation with maternal age, parity, severity of blood pressure and serum albumin. Indian J Physiol Pharmacol. 1999;43(2):193-8.
22. Sardana D, Nanda S, Kharb S. Thyroid hormones in pregnancy and preeclampsia. J Turkish Ger Gynecol Assoc. 2009;10(3):168-71.
23. Dhananjaya B, Kumaran DS, Venkatesh G, Murthy N, Shashiraj H. Thyroid Stimulating Hormone (TSH) Level as a Possible Indicator of Pre-eclampsia. J Clin Diagnostic Res. 2011;5(8):1542-3.
24. Larijani B, Marsoosi V, Aghakhani S, Moradi A, Hashemipour S. Thyroid hormone alteration in pre-eclamptic women. Gynecol Endocrinol. 2004;18(2):97-100.
25. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: An endothelial cell disorder. Am J Obstet Gynecol. Elsevier; 1989 Nov 11;161(5):1200–4.
26. Muzammil S, Khayyam UK, Siddiqui N ali. Serum protein ratio in normal and pre-eclamptic women of primiparous and multiparous in relation to age. Int J Basic Appl Med Sci. 2014;4(2):331- 5.
27. Olooto W, Amballi A. Assessment of Total Protein, Albumin, Creatinine and Aspartate Transaminase level in Toxemia of Pregnancy. J Med …. 2013;12(8):791-6.
28. Demers L, Spencer C. The Thyroid: pathophysiology and thyroid functioning testing. In: Tietz textbook of clinical chemistry and molecular diagnostics. 4th ed. Elsevier; 2006. p. 2053-96.
29. Osathanondh R, Tulchinsky D, Chopra IJ. Total and free thyroxine and triiodothyronine in normal and complicated pregnancy. J Clin Endocrinol Metab. 1976;42(1):98-104.
30. Lao TT, Chin RK, Swaminathan R, Lam YM. Maternal thyroid hormones and outcome of preeclmaptic pregnancies. An Int J Obstet Gynaecol. 1990;97(1):71-4.
31. Tolino A, de Conciliis B, Montemagno U. Thyroid hormones in the human pregnancy. Acta Obstet Gynecol Scand. 1985;64(7):557-9.
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