IJCRR - 5(4), February, 2013
DO STATINS HAVE POTENTIAL AS ANTI OSTEOPOROTIC DRUGS AND CAN THEY BE USED FOR PREVENTION OR TARGETING OSTEOPOROSIS: A REVIEW
Author: Karmajeet Rath, Biswa Bhusan Mohanty, Sanjay Kumar, Pramila Nayak, Jagannath Sahoo
Inhibitors of HMG-CoA reductase enzymes, which are statins, are well known and much prescribed drugs for lowering of cholesterol and used for dyslipidemia. But, they have also been shown across various studies to stimulate bone formation. In bone cells, these inhibitors have been known to increase the gene expression of bone morphogenetic protein-2, thereby helping in osteoblastic differentiation, with some effects also on osteoclastic inhibition. The findings that statins can increase bone formation and thereby mass of bone, can be helpful in preventing bone fractures and improving osteoporosis, which is a condition of marked bone loss. Hence, it is reviewed herein that HMG-CoA reductase inhibitors can be a great way, probably a futuristic drug for osteoporotic treatment and prevention. Keywords: HMG-CoA reductase inhibitors, osteoporosis
Keywords: HMG-CoA reductase inhibitors, osteoporosis, osteoblasts, statins, bone metabolism, fracture
Karmajeet Rath, Biswa Bhusan Mohanty, Sanjay Kumar, Pramila Nayak, Jagannath Sahoo. DO STATINS HAVE POTENTIAL AS ANTI OSTEOPOROTIC DRUGS AND CAN THEY BE USED FOR PREVENTION OR TARGETING OSTEOPOROSIS: A REVIEW International Journal of Current Research and Review. 5(4), February, 73-81
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