IJCRR - Vol 05 Issue 03, February, 2013
HISTOPATHOLOGICAL SPECTRUM OF SINONASAL MASSES -A STUDY OF 162 CASES.
Author: Seema K. Modh, K. N. Delwadia, R. N. Gonsai
Lesions of the sinonasal region are commonly encountered in clinical practice and important from clinical and pathological perspectives as they have a varieties of histological patterns.
Aims and Objectives:
1) To study the incidence of benign and malignant lesions of sinonasal region.
(2) To study distribution of various lesions for sex differences and symptomatology.
(3) To compare the findings of the study with other studies. Methods: Present study included 162 polypoidal lesions of the nasal cavity. The study period constituted from December 2011 to October 2012. All the tissues were fixed in 10% buffered formalin, processed, stained with H and E and studied for various histopathological patterns. Periodic acid Schiff’s and reticulin stains were used wherever necessary. Results: Among 162 cases, 110 cases (67.11%) were nonneoplastic and 52 cases (32.09%) were neoplastic. Among the non-inflammatory lesion, nasal polyp (83.64%) was the commonest lesion followed by fungal infection. Benign tumours (69.23%) were more frequent than malignant tumours (30.77%). Among benign neoplastic lesions, angiofibroma (41.67%) was commonest and hemangioma (19.4%) was the next common lesion. All lesions were common in second and third decades, with male predominance. Malignant lesions were comparatively less to that of benign lesions. Squamous cell carcinoma was most common malignant lesion. Conclusion: Categorizing the sinonasal lesions according to histopathological features into various types, helps us to know the clinical presentation, treatment, clinical outcome and prognosis of the disease, so all polypoidal lesions need histological examination.
Keywords: Nonneoplastic, Neoplastic, Benign, Malignant.
Seema K. Modh, K. N. Delwadia, R. N. Gonsai. HISTOPATHOLOGICAL SPECTRUM OF SINONASAL MASSES -A STUDY OF 162 CASES. International Journal of Current Research and Review. Vol 05 Issue 03, February, 83-91
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Inflammatory polyp : Proliferation of tubular glands lined by ciliated, respiratory-type epithelium and goblet cells, without nuclear atypia. The stroma is edematous with inflammatory cells and eosinophils
Mucormycosis. Hyphae are broad, often distorted and frequently appear twisted. Branching is rightangled (arrow) and septae are absent (PAS stain).
Non-keratinizing Squamous cell carcinomashowing many broad, interconnecting bands of neoplastic epithelium without keratinization characterizes this lesion and pleomorphic cells with loss of polarity and marked mitotic activity are present (HandE section)