IJCRR - 5(3), February, 2013
Pages: 76-82
HISTOPATHOLOGICAL STUDY OF MENINGIOMA IN CIVIL HOSPITAL, AHMEDABAD
Author: Smita Shah, R. N. Gonsai, Rinku Makwana
Category: Healthcare
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Abstract:
Objective: This study was done to determine the clinical and histological pattern of intracranial meningioma, to determine the sociodemographic characteristic and clinical presentation and correlate this to the clinical patterns of intracranial meningioma, to find out the anatomical location of meningioma and to document the WHO histological grade of meningioma.
Materials and Methods: We have studied 51 cases of meningioma. Meningioma was diagnosed primarily by contrast enhanced CT Scan and Magnetic Resonence Imaging (MRI) of brain. This was confirmed by histopathological examination. Histopatholgical results were examined according to age and sex distribution, anatomical location of tumor, histological type and WHO grading of tumor. Correlation of clinical features and radiological findings were made with histpathological results.
Results and conclusion: Most of the sufferer was female 34 (67%). The commonest age group was 40-59 years. The commonest site of tumor was convexity of brain 26 (60%). The commonest histopathological type was meningotheliomatous meningioma 20 (39%). The 92% of the meningioma was WHO GRADE I tumor.
Keywords: meningioma, WHO grading of meningioma, prognosis of meningioma
Citation:
Smita Shah, R. N. Gonsai, Rinku Makwana. HISTOPATHOLOGICAL STUDY OF MENINGIOMA IN CIVIL HOSPITAL, AHMEDABAD International Journal of Current Research and Review. 5(3), February, 76-82
References:
1. Cushing H. The meningiomas (dural endotheliomas): their source, and favoured seats of origin. Brain 1922;45:282 316.
2. Kleihues P, Burger PC, Scheithauer BW. Histological typing of tumours of the central nervous system. 2nd ed. World Health Organization. Berlin: Springer Verlag, 1993:30.
3. Das A. Tang WY. Smith Dr. meningiomas in Singapore, demographic and biological characteristics. J Neurooncol 2000.47, 153 60.
4. Al Mefty O, Kersh JE, Routh A, Smith RR. The long term side effects of radiation for benign brain tumors in adult. J Neurosurg 1990; 73; 502 512.
5. Christensen HC, Kosteljanetz M, Johanses C. Incidence of gliomas and meningiomas in Denmark. 1943 to 1997. Neurosurgery 2003, 52: 1327 34.
6. Lang FF, Macdonald OK, Fuller GN, DeMonte F. Primary extradural meningiomas. A report on nine cases and review of the literature from the era of computerized tomography scanning. J Neurosurg 2000,93:940 950.
7. Kleihues P, Cavenee WK, International Agency for research on cancer, Pathology and genetics of tumors of nervous systems, Lyons: IARC Press 2000
8. Perry A, Scheithauer BW, Staff ord SL, Lohse CM, Wollan PC. “Malignancy” in meningiomas: a clinicopathologic study of 116 patients, with grading implications. Cancer 1999; 85: 2046–56.
9. Bollag RJ, Vender JR, Sharma S. Anaplastic meningioma: Progression from atypical and chordoid morphotype with morphologic spectral variation at recurrence. Neuropathology 2010;30(3):279 87.
10. Campbell BA, Jhamb A, Maguire JA, Toyota B, Ma R. Meningiomas in 2009: controversies and future challenges. Am J Clin Oncol 2009;32(1):73 5.
11. McGovern SL, Aldape KD, Munsell MF, Mahajan A, Demonte F, Woo SY. A comparison of World Health Organization tumor grades at recurrence in patients with non skull base and skull base meningiomas. J Neurosurg 2010;112(5):925 33.
12. Zorludemir S, Scheithauer BW, Hirose T, Van Houten C, Miller G, Meyer FB. Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. Am J Surg Pathol 1995; 19: 493–505.
13. Couce ME, Aker FV, Scheithauer BW. Chordoid meningioma: a clinicopathologic study of 42 cases. Am J Surg Pathol 2000; 24: 899–905.
14. Tong tong W, Li Juan B, Zhi L, Yang L, Bo Ning L, Quan H. Clear cell meningioma with anaplastic features: case report and review of literature. Pathol Res Pract 2010;206(5):349 54.
15. Maier H, Ofner D, Hittmair A, Kitz K, Budka H. Classic, atypical, and anaplastic meningioma: three histopathological subtypes of clinical relevance. J Neurosurg 1992;77:616 23.
16. Kim EY, Weon YC, Kim ST, et al. Rhabdoid meningioma: clinical features and MR imaging findings in 15 patients. AJNR 2007;28(8):1462 5
. 17. Vranic A, Popovic M, Cor A, Prestor B, Pizem J. Mitotic count, brain invasion, and location are independent predictors of recurrence free survival in primary atypical and malignant meningiomas: a study of 86 patients. Neurosurgery 2010;67(4):1124 32.
18. Kane AJ, Sughrue ME, Rutkowski MJ, et al. Anatomic location is a risk factor for atypical and malignant meningiomas. Cancer 2011;117(6):1272 8.
19. Haradhan Deb Nath, MD mainuddin, MD kmal Uddin, Ehsam mahmood et al, surgical outcome of supratentorial meningioma. A study of 25 cases. JCMCTA 2009;41 44.
20. Alkyildiz EU, Oz B, Comunoglu N, Aki H et al. The relationship between histomorphological characteristics and ki67 proliferation index in meningioma Bratisl Lek listy 2010;111(9) 505 509.
21. Joseph. Wanjeri et al. Histology and clinical pattern of meningiomas at the Kenyatta National Hospital Nairobi, Kenya. A thesis submitted for the award of the degree of master of medicine in neurosurgery, University of Nairobi, 2011.


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