IJCRR - Vol 05 Issue 24, December, 2013
CORRELATION BETWEEN BREAST CANCER AND RISK FACTORS
Author: R. A. Mustafa, A. Abdelbadie, Ihsan Osman, H. Omer
To evaluate the correlation between breast cancer and many risk factors which include family history of breast cancer, history of benign breast disease, obesity, age at menarche, menopause, abortions, older ladies at first full-term pregnancy, parity, lactation. 328 females, all originating from the Sudanese, were eligible for analysis. An age-stratified random sample of 100 women was used as a control group. The interview followed a structured questionnaire. 153 (47%) of patients their age <50 years, 175 (53%) age >50 years, 148 (45%) of the patients from rural areas, while 180 (55%) from urban areas. There is association between breast cancer and residence. Premenopausal patients were 158 (48%) and postmenopausal patients were 170 (52%), there is statistically significant difference. There is no statistically significant difference observed between patients approaching menopause at an age of >50 years and those approach it at age <50 years. The study revealed statistically significant difference between breast cancer and age at menarche less than 12 years, history of breast cancer in a first degree relative, parity and body mass index, whereas, no significant difference was noticed with history of abortion or miscarriage, lactation, use of medication to suppress lactation. The study confirmed an etiological association between breast cancer and Many risk factors have been identified either genetic factor which include family history of breast cancer, obesity and high fat diet or hormonal factors which include female sex, risk increasing with age, long interval between menarche and menopause and older ladies at first full-term pregnancy have resulted in several aetiological hypotheses.
Keywords: Breast cancer, risk factors, menopause.
R. A. Mustafa, A. Abdelbadie, Ihsan Osman, H. Omer. CORRELATION BETWEEN BREAST CANCER AND RISK FACTORS International Journal of Current Research and Review. Vol 05 Issue 24, December, 57-60
- American Society of Clinical Oncology: Statement of the American Society of Clinical Oncology: genetic
- testing for cancer susceptibility, adopted on February 20, 1996. Journal of Clinical Oncology 14(5): 1730
- 1736, 1996.
- Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet 347(9017): 1713-1727, 1996.
- Chaney AW, Pollack A, Mcneese MD, et al.: Primary treatment of cystosarcoma phyllodes of the breast. Cancer 89(7): 1502-1511, 2000
- Connor CS, Tawfik, OW, Joyce AJ, Davis MK, Mayo MS and. Jewell WR.A comparison of prognostic tumor markers obtained on image-guided breast biopsies and final surgical specimens, Am J Surg 184 (2002), pp. 322–324.
- Jemal A,Siegel R,Ward E,Murray T,Xu J,Thun MJ: Cancer statistics,2007.CA Cancer J Clin 2007, 57:43-66.
- Parkin DM, Muirc CS, Whelar SL, Gao YT, Ferlay J, Powel J. Cancer incidence in five continents 120- International Agency for Research on Cancer (IARC). Lyon. 1992.
- Souliami R, Tannock I, Hobenberger P, Horiot JC. The Oxford textbook of oncology. Oxford University, 2001.
- Statement of the American Society of Clinical Oncology on potential misconduct in South African trial - improprieties in breast cancer study of high-dose chemotherapy reported to ASCO [Internet]. Alexandria, Va: American Society of Clinical Oncology, 2000.
- Underwood JCE. General and systematic pathology, 2nd ed. Churchill Livingstone; 1996. PP . 82.
- Willett W. C. Diet and breast cancer . Journal of Internal Medicine
2001; 249 (5)395