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IJCRR - 6(10), May, 2014

Pages: 64-76

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COMPARISON OF 'CUT AND PASTE (USING FIBRIN GLUE)' VS 'CUT AND SUTURE (USING 8-0 VICRYL SUTURES)' TECHNIQUES OF PTERYGIUM SURGERY

Author: Kumar Nishant, Vireshwar Prasad, Asif Shahnawaz, Muazzam Ali Akbar

Category: Healthcare

Abstract:Background: In recent times, the universal trend toward simpler, quicker and more comfortable surgical procedures have fostered the development of suture-less techniques and hence use of fibrin glue for attaching conjunctival autograft after pterygium excision. Objectives: To assess and compare the mean surgical time, post-operative discomfort and recurrences among patients undergoing Pterygium excision and conjunctival autografting using fibrin glue; with Pterygium excision and conjunctival autografting using 8-0 Vicryl sutures. Materials and methods: 60 patients with primary pterygium randomized into two groups. Group A (n=30) underwent autografting using fibrin glue; Group B (n=30) underwent autografting using 8-0 Vicryl suture. P-value < 0.05 was considered statistically significant. Surgical times were noted as: Total surgical time from 1st conjunctival cut to removal of lid speculum, time for excision of pterygium and time to secure graft on the bed. Post operative discomfort was assessed using pretested questionnaires Results: Mean surgical time for Pterygium excision with conjunctival autografting using fibrin glue (15.86min) is significantly less as compared to sutures(27.93min); P=0.001. Post-operative discomfort was significantly less in cases of fibrin glue (10% patients) in comparison to suture group (56.6%patients). The observed difference between the recurrence rates in the group A (3.3%) and Group B (20%) was statistically significant. Conclusion: Fibrin glue reduces the surgical time, post-operative discomfort to the patients and has lower recurrence rates in comparison to conjunctival autografting using sutures following pterygium excision.

Keywords: Pterygium, Conjunctival autografting, 8-0 Vicryl suture, Fibrin glue

Full Text:

INTRODUCTION

Pterygium is one of the oldest diseases known in the history of medicine. It is a common condition in India, which is part of the ?Pterygium belt? described by Cameron1 . Besides the cosmetic appearance, the patient may complain of discomfort with recurrent redness of eye, swelling, tearing, burning sensation and occasionally pricking or gritty sensation. When the axial area of the cornea is invaded, vision gets increasingly affected. This occurs even before the Pterygium itself has reached the area, because of irregular astigmatism produced by corneal folds. In advanced Pterygium, ocular motility may be restricted leading to diplopia in certain field of gaze. Though the disease is known since time immemorial, no satisfactory treatment has yetbeen evolved up till now. Among the eye diseases which often are prone to recurrence, Pterygium is one of the commonest. The treatment of Pterygium is mainly surgical. A wide range of surgical maneuvers for removal of Pterygium have been reported. Bare sclera is the simplest method of Pterygium excision but is associated with a very high recurrence rate ranging from 24% to as high as 89%. Pterygium recurrence after bare sclera excision may be highly aggressive and in severe cases ocular morbidity may far exceed the primary lesion. To avoid this, adjunctive treatment such as ß-irradiation, Thiotepa, Mitomycin-C, 5-Fluorourail etc are used. Newer techniques include conjunctival autografting with or without limbal stem-cell transplantation and amniotic membrane grafting. Of all these newer methods, conjunctival autografting is most commonly performed and is associated with low rates of recurrences. The autograft can be attached to bare sclera with the help of 8-0 Vicryl suture; this is associated with increased surgical time, more post-operative pain, discomfort, watering and prolonged healing time. In recent times, the universal trend toward simpler, quicker and more comfortable surgical procedures have fostered the development of sutureless techniques and hence use of tissue adhesives for attaching conjunctival autograft. This technique claims to reduce the surgical time, cause less postoperative pain, irritation, watering, induce less inflammation, reduce healing time and recurrences. Fibrin glue is the most recent among all adhesives and is gaining acceptance world over for use in treatment of various ocular conditions. RelisealTM (manufactured by Reliance Life Sciences)is a two component tissue adhesive namely human fibrinogen and human thrombin. The resultant mixture simulates the natural physiological phenomenon of blood clotting at the bleeding site and forms a viscous clot. Thus, the formed clot acts like a seal to arrest bleeding or glue tissues. The fibrin clot also supports wound

healing process. It gets absorbed over several days to weeks by the naturally occurring endogenous fibrinolytic enzymes. Hence, a study was conducted to assess and compare the mean surgical time, post-operative discomfort and recurrences among patients undergoing Pterygium excision and conjunctival autografting using fibrin glue; with Pterygium excision and conjunctival autografting using 8-0 Vicryl sutures.

MATERIALS AND METHODS

In view of different techniques for Pterygium surgery, a prospective hospital based study has been conducted during March 2010 to September 2011to compare ?Cut and paste (Sutureless) technique‘ with ?Cut and suture technique‘ of pterygium surgery in terms of mean surgical time, postoperative discomfort and complications and recurrences. Written informed consent was obtained from all the participants before enrolment in the study and clearance from Institution‘s Ethics Committee was taken

Inclusion Criteria:

Study population was selected from the patients attending Ophthalmology Out-patient Department of the hospital with primary pterygium. Selected patients (total number 60) were randomly divided into 2 groups: Group A (n=30 patients): Corneo-scleral resection of pterygium with conjunctival autografting using Fibrin Glue. Group B (n=30 patients): Corneo-scleral resection of pterygium with conjunctival autografting using 8-0 Vicryl Sutures. Exclusion Criteria: 1. Cases with cystic, atrophic or inflamed pterygia. 2. Patients with associated ocular surface disorders like Sjogren‘s syndrome. 3. Patient with recurrent pterygia. 4. Pregnant patients and lactating mothers.All patients in the study were subjected to a thorough general and ocular examination.

METHODOLOGY

All surgeries were performed by a single experienced surgeon, always using the same equipments, technique and materials in each group except instead of using fibrin glue in Group A; 8-0 Vicryl sutures were used to fix conjunctival autograft on bare sclera in Group B. Surgical Steps: 1. Peribulbar block 2. Dressing and draping 3. Superior rectus bridle suture 4. Dissection of pterygium from apex to periphery 5. Dissection of conjunctival autograft from supero-temporal area 6. Graft secured either by 8-0 Vicryl sutures or by Fibrin Glue Securing the graft in bare sclera bed was done: A. With Sutures Once the graft is secured with the 4 cardinal sutures (8-0 Vicryl Suture) at the 4 corners, the forniceal edge can then be sutured with further interrupted sutures which need not include the episclera. These help fix the graft in position and avoid displacement of the graft, which can occur as the tissue around the sclera beds contracts and retracts in the postoperative period. B. With Fibrin Glue The Fibrin glue kit (RelisealTM, manufactured by Reliance Life Sciences Laboratories, India) contains 2 major components in separate vials: 1) Freeze dried human fibrinogen 2) Freeze dried human thrombin The kit also contains: 1) Aprotinin solution (Bovine) — 3000 and 1500 kallikrein inhibitor units (kiu/ml) in 1ml and 0.5ml units respectively. 2) 1 × 5 ml ampoule of sterile water for injection 3) 4×2ml syringes for reconstitution and application, 4) 4×21G sterile needles for aspiration of the two components; 2×20G blunt application needles. 5) Fibrin glue applicator with two mixing chambers and 1 plunger guide.

Safety and viral inactivation of the product: The product is screened for HIV 1 and 2, Hepatitis B virus, HCV, Parvo virus and HAV. Solvent Detergent Technology is used to inactivate lipid coated viruses. Though, there is a remote possibility of an unknown infectious agents be present in these products.

PHARMACOLOGY

The fibrin adhesion system initiates the last phase of physiological blood coagulation cascade.

The locally applied mixture quickly sets to form a milky white to translucent mass which continues to gain strength within 2 hrs following application. As wound healing progresses, increased fibrinolytic activity is induced by plasmin and decomposition of fibrin to fibrin products is initiated. Proteolytic

degradation of fibrin is inhibited by Aprotinin (A plasmin inhibitor). The graft is excised and placed on the cornea – with the stromal side facing the surgeon and the limbal edge of the graft adjacent to the limbus of the scleral bed. The reconstituted components of fibrin glue are mixed just at the site of application of the recipient surface by specially designed ?Fibrin Glue Applicator‘. The ensuing reaction results in the formation of sticky fibrin, which anchors the graft to the sclera bed. The graft is smoothed into position and the edges are co-apted to bring about a secure adhesion of the graft to the bed and the conjunctival edges. The process of adhesion usually takes about 45 to 60 seconds, which is time enough for the surgical manipulations. The rest of the procedure is as described before. Each 1 ml reconstituted solution was used in 6-8 patients. Postoperative Care

At the conclusion of surgery, 0.5cc dexamethasone and gentamycin is injected subconjunctivally and the eye is firmly patched with antibiotic eye ointment for 24 hours. Starting the next day, topical steroids are used at 2 hourly intervals and then tapered gradually over the next 6 weeks. Antibiotic eye ointment is also used frequently in the postoperative period. Surgical time was noted as follows: 1. Total surgical time from 1st cut of conjunctival to removal of lid speculum 2. Time for excision of pterygium 3. Time to secure graft on the bed (Surgical time was approximated to nearest round figures in minutes.) Post-operatively patients were examined on 1st postoperatively day, after 7 days, one month, three months and six months. On 1st post-operatively day following were observed: Grading of postoperative discomfort(graded on scale 0 to 3 using pretested questionnaires):

Graft success was defined as an intact graft by 4th week after surgery Graft failure was defined as detachment of graft by 4 th week after surgery. Recurrence was defined as proliferating conjunctival tissue extending across the limbus more than 1 mm onto the cornea within surgical field. Graft status: properly placed or displaced or lost. In subsequent visit following things were assessed. 1. Appearance of the graft (any sign of rejection or misplacement) 2. Any sign of recurrence 3. Patients‘ comfort.

Statistical Analysis

Data analysis has been done as: All data has been summarized as frequency tables and percentages have been worked out. The mean, standard deviation and the standard error of difference have been calculated. Student T-test and Z-test have been applied wherever appropriate to find out the difference between the two groups. Asymptomatic significance (P-value) is calculated for all the variables through these statistical tests. A ?Pvalue‘ of less than 0.05 has been considered significant.

RESULTS

Of the 60 patients enrolled in study, 40 (66.67%) were male and 20 (33.33%) were female. The age distribution of the patients shows that the majority of the patients are between 31-40 years of age. (Table 1) In group A mean total surgical time for excision of pterygium and graft placement was 15.86 minutes with SD 1.187 Mean pterygium excision time was 6.2 minutes and SD 1.082 Mean time to secure graft in bed was 9.66 minutes and SD 1.588 (Table 2) In group B mean total surgical time for excision of pterygium and graft placement was 27.93 minutes with SD = 2.789 Mean pterygium excision time was 4.66 minutes and SD = 0.617 Mean time to secure graft in bed was 23.26 minutes and SD 2.49 (Table 3) Comparing (A1 B1), P value = 0.001 i.e. the total time taken for operation is comparable and highly significant* i.e. notably less in A1. Comparing (A2 B2), P value = 0.24 i.e. it is not significant. Comparing (A3 B3), P value = 0.013 and is significant* i.e. time taken to secure graft to bed is much less than that of sutures. (Table 4) Three patients (10%) in Group A and 6 patients (20%) in Group B developed subconjunctival haemorrhage which resolved completely within 4th postoperative week. Three patients (10%) in each Group A and B developed transient graft edema which gradually resolved upon treatment with topical corticosteroid within 4th post-operative week. Two patients (6.6 %) in each Group A and B had loose graft on 1st post-operative day out of which 1 patient in each group developed graft failure by 4th post-operative week while remaining 1 patient in each group showed spontaneous healing and reattachment. (Table 5) In group A, out of 30 eyes of patients, 1 patient developed recurrence, so recurrence rate in group A is 3.3%

In group B, out of 30 eyes of patients, 6 developed recurrences, and so recurrence rate in group B is 20%. The difference of recurrence rate between two groups A and group B is statistically significant or not was tested by following formula. The standard error of difference is 8.0 where as observed difference (20 – 3.3) was 16.7. The observed difference between the two groups is more than twice the S.E. of difference i.e. 2 X 8 = 16.0. Therefore observed difference between recurrence rates was significant*. (Table 6) Group A showed graft failure rate of 3.3% while group B showed graft failure rate of 13.2. Standard error of difference is 6.99 where as observed difference (13.2 – 3.3) is 9.9 which is less than twice of standard error of difference. (Not statistically significant). (Table 7) In Group A, 27 patients (90%) out of 30 experienced no post-operative discomfort while 3 patients (10%) experienced mild post-operative discomfort (Grade 1, assessed using questionnaires) In group B, 13 patients (43.3%) out of 30 experienced no post-operative discomfort while 16 patients (53.3%) experienced mild (Grade 1) postoperative discomfort. 1 patient (3.3%) experienced moderate severity of discomfort (Grade 2). None of the patients in either group experienced any Grade 3 (severe) post-operative discomfort.

DISCUSSION

The present study was carried out to assess and compare the mean surgical time, post-operative discomfort and recurrences among patients undergoing Pterygium excision and conjunctival autografting using fibrin glue; with Pterygium excision and conjunctival autografting using 8-0 Vicryl sutures. Surgical time - comparison between group A and B In group A (Fibrin glue group); the mean total surgical time for excision of pterygium and graft placement was 15.86 minutes with SD 1.187 in comparison to Group B (8-0 Vicryl Suture) where

it was 27.93 minutes with SD 2.789 (P = 0.001; Highly significant). Mean pterygium excision time in Group A and B were 6.2 minutes (± 1.082 SD) and 4.66 minutes (± 0.617SD) respectively (P = 0.24; Not significant). Mean time to secure graft in bed was 9.66 minutes (± 1.588SD) in Group A and 23.26 minutes (± 2.49 SD) in Group B (P=0.013, Significant) [Table 1 and Table 2] Thus, it is seen that time taken for surgery is definitely less for the fibrin glue group i.e. Group A (Table 3). These findings corroborate with studies performed by Koranyi et al (2003)2 on 43 patients with pterygium. Average time was 9.6minutes for glue and 18.5 min. for sutures (p < 0.001). Jiang J, Yang et al (2008)3 also found that the average operating time was significantly shorter (p < 0.001) in fibrin sealant group as compared to suture group. Bahar I, Weinberger D et al (2007)4 noted average operating time to be 16 minutes (range 14-16 minutes) in the fibrin glue group and 28 minutes in Vicryl suture group. Post-operative complications In this study subconjunctival haemorrhage was found to be more commonly associated with conjunctival autografting using 8-0 Vicryl studies, in contrary to the study by Srinivasan S et al (2009)5 which did not find any significant difference. Increased incidence of subconjunctival haemorrhage in group B may be attributed to greater traumatizing of conjunctiva during suturing process (Table 4). In this study, no other complications were found to be more common in a particular group.

RECURRENCE

The observed difference between the recurrence rates in the 2 groups was statistically significant (Table 5). This may be attributed to better and smooth anatomical approximation of conjunctival autograft on recipient bed on application of fibrin glue. Also, edges may be co-apted to bring a secure adhesion to the bed using fibrin glue promoting early graft epithelialization. Moreovergraft positioning might be easier in case of fibrin glue in contrast to Group B wherein graft may have been inadvertently scrolled up resulting in inversion of surfaces leading to graft failure. There were no new cases of recurrence at 6th month postoperative visit. Thus, all recurrences were observed within 3 months post-operatively. The observation corroborates with the study performed by Farid M, Pimazar JR (2003)6 wherein they found recurrence rate in Tisseel group was 3.7% as compared to 20% in sutured group (P = 0.035). The average time of recurrence was 3.13 months. Hall RC et al (2009)7 also found that at 3 months, there were no recurrences in the glue group and 2 recurrences in the suture group. Karalezli a et al (2008)8 also observed recurrence in 1 case (4%) in the fibrin glue group as compared to 3 eyes (12%) in the suture group (p < 0.05).

Graft status Graft failure was seen 4 times more commonly in suture group than in fibrin glue group. Graft failure rate in Group A was 3.3% while in Group B was 13.2% at 4th week post-pterygium surgery [Table-6]. All cases of graft failure ultimately lead to recurrence of pterygium. The three and six month graft failure rate was unchanged and not significantly different between glue and suture groups. Post-operative discomfort In Group A (Fibrin glue group), 27 patients (90%) out of 30 experienced absolutely no post-operative pain or discomfort while in Group B (Suture group), only 13 patients (43.3%) experienced the same [Table-7]. In Group A, 10 % patients had tolerable symptoms in form of foreign body sensation, watering or itching and were present only occasionally in whole day (graded as mild discomfort) on first post-operative day. None of the patients complained of Grade 2 (moderate) or Grade 3 (severe) discomfort.In Group B, a major fraction of patients (56.6%) experienced some form of ocular post-operative discomfort. 16 patients out of 30 (53.3%) complained of mild discomfort while 1 patient complained of moderate / grade 2 discomfort in the form of persistent watering and foreign body sensation throughout the day which gradually subsided on its own. None of the patient in the group complained of any severe/ grade 3 symptoms. In subsequent visits of the patient at 1 week, 1 month, 3 months and 6 months; none of the patients from either group complained of any ocular discomfort. This study supports the observation made by Karalezli A et al (2008)8 wherein they found the intensity of postoperative pain foreign body sensation irritation and epiphora were significantly lower in the fibrin glue group than in the suture group (p < 0.001) Kim H, Mun H J et al (2008)9 also observed that subjective symptoms disappeared in 23 out of 36 eyes (64%) in one week after surgery and all discomforts subsided within two weeks after surgery in all patients. Bahar I, Weinberger D et al (2007)4 also observed satisfaction to be higher in the fibrin glue group (p < 0.05) than in the suture group. Similar observations were also made by Uy HS, Reyes JM et al (2005)10 .

CONCLUSION

This study shows that pterygium excision with conjunctival autografting using Fibrin Glue reduces the surgical time as compared to securing graft using 8-0 Vicryl Sutures. Also, the post operative discomfort and recurrence rate is significantly less in cases with Fibrin Glue as compared to 8-0 Vicryl Sutures..This may be attributed to biocompatible nature of fibrin glue which avoids complications derived from sutures and diminishes the sensation of a foreign body in the eye following surgery. Thus, patient comfort and satisfaction is significantly higher when fibrin glue is used for

conjunctival autograftingbut the cost of Fibrin Glue makes it an expensive procedure than conjunctival autografting using Vicryl sutures. Another comparative study may be required to study the feasibility of performinga relatively expensive technique (using fibrin glue) when an inexpensive technique using sutures has been in vogue since long especially in a developing country like India. In due course of time, the cost of fibrin glue is likely to come down; making this novelpterygium surgery technique: ?the procedure of choice of the day‘.

ACKNOWLEDGEMENTS

This dissertation would be wholly incomplete if it did not carry a sincere word of thanks to everyone who has helped us during the course of this study. We wish to express my deep andheartful gratitude to our teachers of Upgraded Department of Ophthalmology Darbhanga Medical College and Hospital, Laheriasarai for their enthusiastic support, keen interest, constant encouragement, patient and friendly guidance at every step of this study.. Wealso thank our colleaguesand supportive juniorsand O.T. staffs of the Upgraded Department of Ophthalmology, Darbhanga Medical College and Hospital, Laheriasarai, whose cooperation and encouragement has helped us to complete this study. We must thank Superintendent Dr. Suraj Nayak and Principal Dr. S.N. Sinha, D.M.C.H, Laheriasarai, for their kind permission to carry out this work. Authors acknowledge the immense help received from the scholars whose articles are cited and included in reference of this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature of this article has been reviewed and discussed. We would fail in my duty if we do not thank all the subjects who volunteered for the study.Last but not the least; we must thank Mr. Manoj Kumar, New Bihar Press, Laheriasarai, Darbhanga for his invaluable co-operation and typing the manuscript of this thesis.

 

 

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A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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