International Journal of Current Research and Review
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IJCRR - 9(8), April, 2017

Pages: 17-20

Date of Publication: 01-May-2017


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A Study of Motor Component of Median Nerve Conduction in Individuals with Type II Diabetes Mellitus

Author: Abiramasundari R., K. Sathish Kumar

Category: Healthcare

Abstract:Background: Diabetes mellitus is a major public health concern that has a significant socioeconomic impact. Diabetic peripheral neuropathy is a common complication in diabetic subjects. Electrophysiological study is commonly used for the assessment of diabetic poly neuropathy.
Aim and Objectives: This study was designed to assess the motor component of median nerve conduction in type II diabetic individuals of more than 5 years duration of illness under regular treatment and also to find out the correlation between the nerve conduction study parameters and the duration of illness.
Subjects and Methods: It is a cross sectional study. The left median nerve conduction study was carried out in 30 type II diabetic subjects in the age range of 40-60 years. The study group includes the diabetics of more than 5 years duration of illness who are regularly attending diabetic outpatient department. The control group includes 30 of age and gender matched healthy volunteers. Nerve conduction parameters like Motor distal latency, Amplitude and Conduction Velocity were measured.
Results: It was observed that the motor distal latency of left median nerve was higher in diabetics than in healthy controls with a statistically significant difference. There was a statistically significant decrease in amplitude and conduction velocity of left median nerve in diabetic subjects than in controls also observed. All the nerve conduction study parameters were found to be correlated with the duration of the illness in diabetics.
Conclusion: The present study insists upon the regular monitoring of nerve function in diabetics to prevent the crippling complications.

Keywords: Peripheral neuropathy, Nerve conduction study, Duration of illness

Full Text:

INTRODUCTION

Diabetes mellitus is a major public health concern that has a significant socioeconomic impact. The long term systemic complications of diabetes are destructive. They are the major cause of morbidity and mortality. They significantly impair the quality of life and also constitute a significant health cost in the society (1, 2).

The International Diabetes Federation has  estimated  the total number of diabetic subjects in the year of 2006 to be around 40.9 million in India and also reported that this level can be increased to 69.9 million by the year 2025 (3).   Diabetic peripheral neuropathy is a common complication in diabetic subjects. The type of neuropathy occurring in the upper limb and the lower limb is known as the Diabetic Peripheral Neuropathy. Diabetic neuropathy may affect motor, sensory and autonomic nerves. It develops slowly and worsens over time. The advanced stage of diabetic neuropathy can cause serious complications such as diabetic foot ulcer and gangrene resulting in amputation. Therefore, early detection of nerve dysfunction is important to provide appropriate care.

Evaluation of neuropathy is commonly done by electrophysiological measurements (4, 5). Nerve conduction study investigates the condition of the large myelinated nerve fibres. The test reveals the normal condition of the nerve and also the abnormality which may be due to the axonal injury and the myelin loss. Parameters of nerve conduction study such as latency, amplitude and conduction velocity are sensitive indicators of diabetic neuropathy (6). They are also specific and reproducible measures (7).

The incidence and prevalence of diabetic neuropathy associated with duration of diabetes affects up to 50% of diabetic subjects after 25 years of disease (8).

The present study was designed to study and compare the motor component of left median nerve conduction in type II diabetes mellitus individuals and controls. Also to correlate the parameters of nerve conduction study with the duration of illness.

SUBJECTS AND METHODS

The institutional ethical committee approval was obtained. Statistically adjusted sample size of 60 was enrolled for the study. In this 30 type II diabetes mellitus subjects of more than 5 years duration of the illness on regular treatment in the age group of 40-60 years of both gender were selected

 as study group from the Diabetic out-patient department. 30 age and gender matched healthy volunteers were selected as controls. The study duration was for the period of six months.

Subjects with Hypertension, Alcoholism, and intake of drugs except oral hypoglycemic drugs, Liver and Kidney diseases, Endocrine disorders were excluded from the study.

After obtaining a written and informed consent from the subjects, questionnaire regarding the personal data and the information pertaining to diabetic status were obtained.

After a complete clinical examination of sensory and motor system, the nerve conduction study was done by using RMS EMG EPII instrument at the neurophysiology laboratory in the department of Physiology. Nerve conduction study was done by the conventional methods with surface electrodes. The action potentials of the motor component of left median nerve were recorded. The nerve conduction study parameters like the distal motor latency (msec), amplitude (microvolt) and conduction velocity (m/sec) were noted. On the basis of duration of illness diabetics were divided into two groups. One group includes diabetics with 5-8 years of illness and the other group 9-12 years of duration illness.

STATISTICAL ANALYSIS

The data was evaluated and analyzed using SPSS version 17. Independent Student’s t test was used to compare the mean value of nerve conduction study parameters between diabetics and controls. Pearson`s correlation coefficient was applied to correlate the duration of the illness and the nerve conduction parameters in diabetic individuals. The probability value of <0.05 was considered as significant.

RESULTS

In this study 30 diabetic subjects of more than 5 years duration of illness were compared with 30 healthy subjects of same age group and gender. In both groups, 50% were males and 50% were females. The mean age of diabetic subjects was 56±4 years; this was comparable with the controls of 54±5 years.  The mean duration of diabetes was 9 ± 3 years.

On comparison of the nerve conduction study parameters (summarized in Table 1) the distal motor latency was significantly increased in diabetics than controls. The amplitude was significantly decreased in diabetics than in controls. The conduction velocity of left median nerve motor component also significantly decreased in diabetics than in controls.

When compared the nerve conduction velocity with duration of illness showed in Table 2 the conduction velocity significantly decreased with increasing duration. Regarding duration of illness the diabetic subjects grouped in 9-12 years of duration showed a statistically significant reduction of the conduction velocity than subjects with 5- 8 years of illness. All the parameters were found to be correlated with duration of illness in diabetics as shown in Table 3.

DISCUSSION

The aim of the study was   to study and compare the motor component of left median nerve conduction among the type II diabetes mellitus individuals of more than 5 years duration and healthy volunteers and also to correlate the parameters of nerve conduction study with the duration of illness.

Diabetic neuropathy is one of the commonest long term complications of type II diabetes mellitus. Diabetic neuropathy is defined as`` the presence of symptoms and signs of peripheral nerve dysfunction in people with diabetes after exclusion of other causes`` (9). In the study by Dyck PJ et al reported that more than 8% of diabetics attending the diabetic clinic for the first time had peripheral neuropathy (10).When the duration of diabetes increases the presence of peripheral neuropathy also increases (11).

The Electrophysiological abnormalities occur in the following order, median nerve (59%), ulnar nerve (28%), peroneal nerve (28%) and sural nerve (8%) (12). Causes of median nerve involvement are, the metabolic factor (hyperglycemia) and entrapment in carpal tunnel. In diabetic subjects entrapment of median nerve is more common due to connective tissue stiffness and repetitive shear force (13).The sorbitol accumulation in nerve tissues due to hyperglycemia may lead to axonal loss (14). We can delay the progression of diabetic neuropathy if detected early. The proper treatment given in early stages can provide a good outcome. In case of severe or well advanced stage, the treatment offers partial recovery by promoting myelination and axonal regeneration of nerve fibers (15).

The prevalence of diabetic neuropathy varies widely from 10% to 90% on the basis of criteria and methods defining neuropathy. In our study, we observed 73.3% prevalence of neuropathy among the diabetic subjects. The same result was also observed in the previous studies done by Tai TY et al and Kawano et al (2, 16). In our study the higher prevalence rate may be due to the selection of study group from the specialty diabetic outpatient department and also due to the fact that the nerve conduction study is more sensitive and specific method in diagnosis of neuropathy. Zahed Ali et al observed in his study that the median nerve has the highest electro diagnostic abnormalities in diabetic subjects with early neuropathy (17).

In our study, the amplitude and the conduction velocity of the motor component of left median nerve was significantly reduced in the study group when compared with healthy controls. The distal motor latency was significantly increased in diabetics than controls. The same findings was also observed in previous studies done by P Noel et al and Cerizza et al (18, 19).Our study findings are in accordance with the findings of Neelambala Prasad et al (20).They carried out the bilateral median motor nerve conduction study in 40 male diabetics  and  40 healthy male volunteers. In their study they have also concluded the result as reduced amplitude and conduction velocities of median nerve in diabetics than controls.

We also observed when the duration of illness increases the conduction velocity of motor component decreases. Mythili et al in their study found out the prevalence of neuropathy was 63% in those with duration less than 5 years to 90% in those with duration more than 10 years (21). In our study we observed a strong negative correlation between the duration of illness, the amplitude and the conduction velocity. As the duration of diabetes increases the conduction velocity and the amplitude decrease. We also observed a strong positive correlation between the duration of illness and the distal motor latency.

CONCLUSION

The present study shows that the motor component of left median nerve conduction study parameters altered in diabetic subjects.  Our study also proves that the subjects with long duration of illness have increased risk of developing neuropathy in spite of attending regular diabetic clinic. Thus our study validates the need for the regular screening of peripheral nerve function in diabetics for the prompt intervention to reduce the morbidity.

ACKNOWLEDGEMENT

We would like to express our sincere gratitude to all the people who helped us to carry out the study. Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript.  The authors are also grateful to authors / editors /publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

 

 

 

 

 

 

 

 

References:

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3. Sicree R., Shaw J., Zimmet P.-Diabetes and impaired glucose tolerance. In: Gan D, editor. Diabetes Atlas. International Diabetes Fedaration. 3rded.Belgium:  International Diabetes Fedaration: p15-103,2006.                        

4. Hyllienmark L, Bresman T, Ludvigsson J. Subclinical nerve dysfunction in children and adolescents with IDDM. Diabetologia 1995;38:685-92.

5. Holland NR, Stocks A, Hauer Pet al. Intra epidermal nerve fibre density in patients with painful sensory neuropathy. Neurology 1997;48:708-11.

6. Andrew JMB, Arthur IV, JOSEPH CA, Vera B, Eva LF, Roy F, Rayaz AM, Raelene EM, Jay MS, DanZ. Diabetic neuropathies. A statement by the American Diabetes association

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8. Graham W.A., Goldstein R., Keith M., Nesathurai S.-Serial Nerve Conduction studies of rhesus monkey(Macacamulatta) and potential implications for interpretation of human    neurophysiological studies. Ann Indian Acad Neuro. 10: 252-254,2007.

9. Tae Sun Park-Can nerve conduction studies detect earlier and predict clinical diabetic  neuropathy? J Diabetes Invest Vol. 6 No 1, January 2015 P 18-20.

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15.Early photocoagulation for diabetic retinopathy. ETDRS report number.

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Neuropathy. Bangladesh journal of Neuroscience 2008, Vol. 23(1):p36.

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20.Neelambala Prasad, Indu K. Pisharody, M.S. Karandikar, S.A. Diwanji, Pankaja R. Raghav- Comparative Analysis of Electrophysiological Parameters of Median Nerve in Normal and Diabetic Subjects. Indian Medical Gazette-July 2013:261-264.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


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A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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