International Journal of Current Research and Review
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IJCRR - 7(8), April, 2015

Pages: 56-62

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AN EPIDEMIOLOGICAL STUDY OF DETERMINANTS OF DEFAULTER UNDER REVISED NATIONAL TUBERCULOSIS CONTROL PROGRAM IN OLD CITY OF HYDERABAD

Author: Pisudde P. M., Sushma Katkuri, Nithesh Kumar, Taywade M. L.

Category: Healthcare

Abstract:Introduction: In India TB report 2014 it was stated that, out of the estimated global annual incidence of 8.6 million TB cases, 2.3 million were estimated to have occurred in India till 2012. As per WHO, Tuberculosis prevalence per lakh population has reduced from 465 in year 1990 to 230 in 2012. Defaulting from treatment has been one of the major obstacles to treatment management and an important challenge for TB control. To ensure treatment adherence, Directly Observed Treatment - Short Course (DOTS) is a main strategy. It becomes imperative to understand the determinants of default under DOTS so that necessary actions can be taken up to prevent defaults under the program. Hence, the present study was undertaken to study the determinants of default under DOTS. Material and methods: Case control study was carried out in \"Bhavani Nagar\" urban slum area of Hyderabad in old city and study subject were selected. Study duration was from 1st January 2011 to 31 December 2012 and data was collected from June 2013 to July 2013 by interviewing study subjects. The data collected was entered and analyzed using epi_info 6.04d. The study has been conducted after being approval from Institutional Ethical Committee. Results and conclusion: The odds of getting default were 2.4 times more when the study subjects belongs to OBC caste but was not found statistically significant. The risk of getting defaulter was 3.2 times more in study subjects studied less than higher secondary when compared with study subjects studied more than equal to higher secondary but was not found statistically significant. Major reason for defaulting was disappreance of the symptoms i.e. 33.3%, followed by intolerance of drugs(26.1%). It was found that having nuclear family is one of the determinant for defaulting. It was also seen that old cases of TB were associated with defaulting this may be due to the drugs intolerance or due to the disappearance of symptoms or their adherence
to treatment requires more counseling. Defaulting was also found significantly associated with DOTS provider who were from
the health department.

Keywords: Case control study, Tuberculosis, Defaulters

Full Text:

INTRODUCTION

India is the second-most populous country in the world one fourth of the global incident Tuberculosis (TB) cases occur in India annually. In India TB report 2014 it was stated that, out of the estimated global annual incidence of 8.6 million TB cases, 2.3 million were estimated to have occurred in India till 2012. India’s TB control programme is on track as far as reduction in disease burden is concerned. There is 42% reduction in TB mortality rate by 2012 as compared to 1990 level. Similarly there is 51% reduction in TB prevalence rate by 2012 as compared to 1990 level. These estimations were based on Revised National Tuberculosis Control Program (RNTCP) data, prevalence surveys in India conducted between 2007-2010, National Annual risk of tuberculosis infection(ARTI) surveys and mortality surveys conducted in 2005. Tuberculosis prevalence per lakh population has reduced from 465 in year 1990 to 230 in 2012. In absolute numbers, prevalence has reduced from 40 lakhs to 28 lakhs annually. Tuberculosis incidence per lakh population has reduced from 216 in year 1990 to 176 in 2012. [1] Defaulting from treatment has been one of the major obstacles to treatment management and an important challenge for TB control.[2,3] Inability to complete the prescribed regimen which is quite common in selfadministered treatment[4], is an important cause for treatment failure, relapse, acquired drug resistance and on-going transmission of infection[5]. The consequences of default could be disastrous particularly in the context of intermittent Short Course Chemotherapy (SCC) regimens. Directly Observed Treatment - Short Course (DOTS) is a main strategy under RNTCP to ensure treatment adherence, wherein each dose of treatment is given under the observation of a health worker. The adoption of DOTS has given impressive results with higher treatment success being reported from developing[6]and industrialized countries[7]. Yet, default continues to occur in certain situations and is a matter of concern. The challenges encountered while implementing DOTS vary from place to place depending on the geographic terrain, demographic structure and socio-cultural milieu. The major thrust of RNTCP is achieving a cure rate of more than 85%[6]. Strict adherence to Directly Observed Treatment is likely to minimize defaults and is therefore essential for the desired treatment success as shown in study at Bangalore[7]. It becomes imperative to understand the determinants of default under DOTS so that necessary actions can be taken up to prevent defaults under the program. Hence, the present study was undertaken to study the determinants of default under DOTS.

AIMS AND OBJECTIVES

The present study was undertaken to study the determinants of default under DOTS programme

MATERIAL AND METHODS 

Present Case control study was carried out in “Bhavani Nagar” urban slum area of Hyderabad in old city. A “case” was a defaulter TB patient who received anti-TB treatment for one month or more from any source and had not taken anti-TB drugs consecutively for two months or more. All cases which defaulted during 1st January 2011 to 31 December 2012 at Bhavani Nagar area using RNTCP definition were included in the study. The “control” was a case of tuberculosis that has completed treatment during 1 January 2011 to 31 December 2012 and was not a defaulter at any point of time. The Quantitative data was collected for the study purpose from June 2013 to July 2013. The quantitative data was collected by interviewing the defaulters and the persons who have completed the treatment in predesigned and pre-tested questionnaire after taking informed consent. The socioeconomic status(SES) was based on the different ration card provided by state government which mentions the Below poverty line(BPL) and Above poverty line(APL) family. The data collected was entered and analyzed using epi_info 6.04d. The study has been conducted after being approval from Institutional Ethical Committee. The defaulters in the study area were interviewed after informed about the importance of the treatment. If any problem detected, defaulter was counseled for referral.

RESULTS

Table 1 above shows that, maximum numbers of study subjects were from below age of 40 years(86.6%), similar were in cases and controls. Age was not found to be significantly associated with defaulters. Male and female study subjects were approximately equally affected in both cases and controls. Study subjects belonging to OBC caste were more in cases(53.3%) and the general caste were more in controls(73.3%). The odds of getting default were 2.4 times more when the study subjects belongs to OBC caste but was not found statistically significant. Study subjects doing household works and those doing labour work were 53.3% and 46.7% in the cases respectively where as in controls 60% were doing household work and 40 % were in labour. It can be observed from the above table maximum number of study subjects were belonging to Below Poverty Line(BPL) i.e 80% and 20% were in Above Poverty Line(APL) and study subjects were similar in cases and controls both. In above table 1 it can be observed that 26.7% and 73.3% study subjects were from joint and nuclear family respectively in cases and in controls it was vice versa. It was observed that the odds of becoming defaulters was 0.13 times less when the study subject belong to nuclear family compared to joint family and was found statistically significant(p <0.05). When observed in above table 

about educational status, 66.7% and 86.7% study subjects were studied more than equal to higher secondary in cases and control where as 33.3% and 13.3% were studied less than higher secondary level of schooling in both cases and controls. The odds of getting defaulter was 3.2 times more in study subjects studied less than higher secondary when compared with study subjects studied more than equal to higher secondary but was not found statistically significant. From above table 1 it can be seen that study subjects married and unmarried were 60% and 40% respectively in the cases and in control they were 80% and 20%. Odds of getting defaulter was 2.6 in married when compared to unmarried but was not found statistically significant(p >0.05) In the above table 1, it can be observed that 20% study subjects were tobacco consumers in cases and there were no tobacco consumer in the control group. It can be observed from above table that 6.7% study subjects were consuming alcohol and 20% were of the study subjects in control groups were consuming alcohol group and was not having any significance in determining the defaulters. Most of the study subjects in cases were referred by health workers and other (80%) while the in controls they were 73% and there was no significance. Above table shows that among the cases group 26% study subjects migrated while no study subjects migrated in the control group. In above table 1, it can be seen that only 6.7% study subjects in the cases were diagnosed in private hospital while all of the study subjects were diagnosed in government hospital. Above table shows that old TB study subjects were 40% and 13.3% in the cases and control group respectively. Odds of getting defaulter of 4.3 times more in old study subjects compared to newly diagnosed TB and the association was found statistically significant(P < 0.05). Above table 1, shows that in cases group pulmonary and extra pulmonary TB diagnosed study subjects were 46.7% and 53.3% respectively while they were 80% and 20% in respectively in control group. Above table shows that in category of TB, study subjects were 60% in cat I and 40% in cat II in cases group and 86.7% and 13.3% in cat I and cat II respectively in control group. Above table 1, shows that DOTS providers in the cases group were personals in the health system(66.7%) and volunteers were 33.3%. While in control group DOTS providers were personals in the health system(6.7%) and volunteers were 93.3%. The odds of getting defaulter was 28 times more if the DOTs provider was the personal from the health system compared to volunteer and was found statistically significant(p <0.05). Above table shows that study subjects those witnessed side effects after treatment were referred equally by self(40%) and health worker(60) equally in cases group and control group. From above table it can be observed that doctors counseled 46.7% study subjects for continuation of the treatment and health worker to 53.3% study subjects in cases group. In control group it was observed that doctors counseled 66.7% study subjects and health worker 33.3% study subjects for continuation of the treatment.

 

Above table 2 shows that major reason for defaulting was disappreance of the symtoms(33.3%), followed by intolerance of drugs(26.1%). Some study subjects took treatment from private doctor which form 20% of the study subjects.

 DISCUSSION

Socio-Demographic factors

In the present study, the age group of the participants ranges from 16 to 55 years. Majority of the cases (86.7%) and controls (85.6%) were below 40 years of age. We did not find increase in risk of default in higher age groups. But the study by Chandrasekaran et al revealed a higher likelihood of default in age more than or equal to 45 years (15.4%) (AOR=1.9; 95% CI=1.2-3.0)[9]. A study by Chaterjee et al showed that the defaulters significantly increased (p<0.05) with age, the maximum being in the 45-59 years of age and declined thereafter.[10] The difference may be attributed to difference in study setting as well as difference in the study designs. In this study, out of total subjects 50% are male and 50% were female. Among the defaulters male and females are 53.3% and 46.7% respectively. In a study at Hong-Kong , male sex was an important risk factors associated with default (OR=1.5; 95% CI= 1.1-2.1)[11] and a significant association also reported by other studies such as Colomet at Medagaskar[12], Daniel at Nigeria[12]. In Indian study by Jaggarajamma et al significantly higher proportion of defaulter were male (p < 0.01).[14,15]. Higher default rates were associated with being male (AOR=3.4; 95% CI=1.5-8.2) in a study by Santha et al.[16] The difference may be attributed to the difference in study designs used.

In our study, majority of the cases (53.3%) and controls (60%) were household workers. There was no statistically significant difference between occupation of cases and controls (p > 0.05). In a study in India by Balsubramanian et al being employed was the independent risk factors for default (AOR=1.7; 95%CI =1.1–2.4; p < 0.01).[17] But the unemployment was a risk factor independently associated (OR=4.44; 95% CI=2.23–8.86) with default outcome in a study at six Russian regions. [18] The difference may be attributed to the difference in the study settings. In present study, study subjects were belonging to Below Poverty Line(BPL) i.e 80% and 20% were in Above Poverty Line(APL) and study subjects were similar in cases and controls both. The risk of being defaulter was 1.38 times more in BPL patient as compared to patient who was not below poverty line. While the other studies found default rate varied in different economic group. Chaterjee et al reported that with increasing family monthly income, the percentage of defaulters decreased uniformly at DTC Roing. But all defaulters in TMH Jamshedpur were high income group.[19] In the present study, among the defaulters 26.7% were from joint family while in control group they constituted 73.3%. Odds of being defaulter was 0.13 (95% CI=0.22- 1.46) among patients from joint family as compared to nuclear family and was found statistically significant(p <0.05). similar was seen in other studies Social support reduced the default outcome (OR 0.13; 95%CI =0.06– 0.28) in a study at six Russian regions.[17]41 Family support is protective factor for default as seen in a study in Ethiopia (OR = 0.19, 95%CI= 0.08–0.46).[19].34 The literacy rate was higher in both, cases and controls 66.7% and 86.7% respectively with study subject studying upto higher secondary or more. Odds of being defaulter was 3.2 times more common among less the secondary level of education than that of higher secondary educated subjects in the present study and the difference was not statistically significant. In a study at Tiruvallur, 12.7% (OR=1.6; 95% CI=1.0-2.4) of defaulters were illiterate.[9] Illiteracy was the independent risk factor for non-adherence to DOTS after adjusting for confounding factors in study in south India by Gopi et al[21]

Personal factors

In present study, among cases 20% used to consume tobacco compared to none among controls. Tobacco users were more among cases than the controls. A study at Hong Kong by Chang et al showed that there was association between state of smoking and default (OR=3.00, 95% CI =1.41–6.39).[22] The difference may be due to small sample size, bigger study with more sample size is required.

In present study it was observed that 6.7% study subjects in case group and 20% in control group were consuming alcohol. It was insignificanct in determining the defaulters. Studies from India and other countries also showed significant association between defaulters and alcohol use. A study at Uzbekistan shows that individuals who consumed alcohol had a higher risk for default, OR 6.01 (95% CI=1.68 – 19.47).[23] Alcohol abuse was a risk factor independently associated (OR=1.99; 95% CI=1.04–3.81) with default outcome in study at six Russian regions[18]. The default rate was higher among alcoholics in a Swiss study.[24] In India, in a study by Jaggarajamma et al 24% (p<0.01) of drinker are defaulter. [14] The risk factors for default are alcoholism [75 of 274 (27%) vs 73 of 582 (12%); P<0.001] in another study in India at tiruvellur.[15] In a study by Santha T et al higher default rates was associated with alcoholism (AOR=2.2; 95% CI=1.3-3.6).[15] in another study by chandrahekaran V et al 17.1% (2.7;1.8-4.2) of defaulter were alcoholic.[9] Most of the study subjects in cases were referred by health workers and others (80%) while the in controls they were 73% and there was no significance. HIGHER DEFAULT RATES WERE ASSOCIATED WITH DIAGNOSIS BY COMMUNITY SURVEY (AOR=2.1; 95%CI=1.2- 3.6).[25] IN A STUDY BY CHANDRASEKARAN ET AL THE CASES IDENTIFIED AND REFERRED BY THE COMMUNITY SURVEY SHOWED 16.7% (1.8-1.1-3.0) DEFAULT.[9] In present study it was seen that 26.7% of study subject in the cases group migrated and there were not migration in the control group study subject. Other studies such as one in Switzerland stated that default rate was significantly higher among immigrants in a study at Switzerland.[24] In a study in India migration of patient is one of the reasons for default among 24% of patients and is significantly higher among newly diagnosed patients as compared to previously treated Category II cases [21 of 61 (34%) vs. 4 of 43 (9%) p<0.001], and among patients who had resided at the given address for two years or less compared to more than two years (7 of 9 vs. 15 of 64; p<0.001).[13] A study from Bangalore city had reported that 20% of the defaulters had migrated under the DOTS based programme[25]While in cohort study at Tiruvallur 32% of defaulters were due to migration[9]

Diagnostic determinants

In present study 93.3% subject were defaulter in cases which were diagnosed from the government hospital. While in other studies HIGHER DEFAULT RATES WERE ASSOCIATED WITH DIAGNOSIS BY COMMUNITY SURVEY (AOR=2.1; 95%CI=1.2-3.6).[25] IN A STUDY BY CHANDRASEKARAN ET AL THE CASES IDENTIFIED AND REFERRED BY THE COMMUNITY SURVEY SHOWED 16.7% (1.8; 1.1-3.0) DEFAULT.[9]

In present study it was seen that old cases tends to become defaulter and odds is 4.3 and was found statistically significant(p<0.05). It was also seen in study at Hong-Kong, a history of past TB with default are significantly associated with default, (OR=8.2; 95% CI, 4.7- 14.3)[11] and (OR=6.23, 95%CI=1.95–19.91)[22] as seen in two different studies respectively. This significant association(RR= 1.99, 95%CI=1.12–3.54, p = 0.035) is also seen in another study among Brazilian children by da Silva Oliveira et al.[26] Higher default rates are associated with history of previous treatment (AOR 2.8; 95%CI 1.6-4.9) in study by Santha et al.[25] It is independent risk factors for default (AOR=3.9; 95%CI=2.6– 5.6; p < 0.001) in a study by Balsubramanian et al.[17] In present study it was seen that pulmonary cases were 46.7% and 80% in cases and controls respectively but was not found statistically associated with the defaulting Pulmonary TB is significantly associated with default [179 of 865 (21%) vs 7 of 73 (10%); p<0.05] in a study at Tiruvallur.[15] In present study majority of the study subjects in both cases(60%) and controls(86.7%) were from category I. There was not association found among the study subjects when it came to category of treatment. While Category of patient is also a significant risk factor for default as in a study Jaggarajamma et al at Tiruvallur in which (38%), [p<0.001] were CAT-II.[15]

Treatment related factors

In the present study, among study subjects, 66.7% of cases and 6.7% controls were provided medicines by personnel from health department while rest were provided by the personnel from other departments such as anganwadi worker or other volunteers. The difference was statistically significant (p < 0.05). Present study observed that defaulters are less if the DOTS providers are not from the health departments but are volunteers(OR. 28). A study by Gopi et al in South India shows that nongovernmental DOTS provider was the independent risk factors for non-adherence to DOTS after adjusting for confounding factors.[21] In the present study all the study subjects suffered from the side effects and 40% of study subjects in both cases and controls groups were referred by self and remaining 60% study subjects in both cases and controls groups were referred by health workers. Different study in Hong-Kong on treatment side effects was associated with default(OR=13.30, 95% CI=3.23–54.79).[22] Medication side effect was significantly associated with defaulting (OR =4.20, 95%CI=1.51–11.66) in a study at Ethiopia.[20] In present study, among the cases and controls 46.7% and 66.7% of the subjects were advised and counseled for regularity, duration and the side effects by doctor. Association was not found statistically significant. While other study by Chatterjee et al shows that lack of motivation was significantly associated with default.[10]

Causes of defaulting

In the present study, the important reasons quoted by the defaulters are disappearance of symptoms (33.3%), intolerance to drugs (26.7%), and private treatment (20.0%). In a study by Chaterjee et al the indifference in improvement of symptom was reasons for defaulting. [10] In another study by Gopi et al, loss of wages was identified as an additional independent risk factor for default.[22]

CONCLUSION

To conclude, in the present study it was found that having nuclear family is one of the determinant for defaulting as continuous source of motivation is necessary for compliance of treatment by family members. It was also seen that old cases of TB were associated with defaulting this may be due to the drugs intolerance or due to the disappearance of symptoms or their adherence to treatment requires more counseling. Defaulting was also found significantly associated with DOTS provider who were from the health department this may be due to stigma attached to the disease where study subjects preferred to take medicines from other volunteers. Other determinants such as use of tobacco, migration and place of diagnosis of the study subjects were not studied properly due to less samples of study subjects. Further studies needs to be planned with more sample size so that their determinants can be looked closely for the association with defaulting. Important reasons quoted by the defaulters were disappreance of the symptoms(33.3%), followed by intolerance of drugs(26.1%), treatment from private doctor (20%) and others. The limitation of the present study should be kept in mind as it was a small scale study based on a small sample. Hence, further research is required to confirm our findings.

ACKNOWLEDGEMENT

Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

 

References:

1. Central TB division, DGHS, Ministry of Health and Family welfare. TB India 2014, RNTCP Status Report. New Delhi; 2014.

2. Snider DE Jr. An overview of compliance in tuberculosis treatment programmes; Bull Int Union Tuberc 1982; 57: 247-52.

3. Brudney K, Dobkin J. Resurgent tuberculosis in New York City: human immunodeficiency virus, homelessness, and the decline of tuberculosis control programs; Am Rev Respir Dis 1991; 144: 745-79.

4. Davidson BL. A control comparison of directly observed therapy vs self-administered therapy for active tuberculosis in the urban United States. Chest 1998; 114: 1239-43.

5. Weis SE, Slocum PC, Blais FX, King B, Nunn M, Matney GB et al; The effect of directly observed therapy on the rates of drug resistance and relapse in tuberculosis; N Engl J Med. 1994; 330: 1179-84.

6. Khatri, G.R., Frieden, T.R.; The status and prospects of tuberculosis control in India; Int J Tuberc Lung Dis 2000; 4(3): 193-200.

7. Sophia Vijay, VH Balasangameswara, PS Jagannatha, VN Saroja, P Kumar. Defaults among tuberculosis patients treated under DOTS in Bangalore city : a search for solution. Ind. J Tub., 2003, 50,185

8. Frieden TR, Fujiwara PI, Washko RM, Hamburg MA. Tuberculosis in New York City-turning the tide. N Engl J Med. 1995 Jul 27;333(4):229-233.

9. Chandrasekaran V, Gopi P, Subramani R, Thomas A, Jaggarajamma K, Narayanan P. Default during the intensive phase of treatment under DOTS programme. Indian J Tuberc 2005;52:197-202.

10. Chatterjee P, Banerjee B, Dutt D, Pati RR, Mullick AK. A complete evaluation of factors and reasons for defaulting in tuberculosis treatment in the state of West Bengal, Jharkhand and Arunachal Pradesh. Indian J Tuberc, 2003,50:17-22.

11. Yeung MC, Noertjojo K, Leung CC, Chan SL, Tam CM. Prevalence and predictors of default from tuberculosis treatment in Hong Kong Hong Kong Med J 2003;9:263-68.

12. Comolet TM, Rakotomalala R, Rajaonarioa. Factors determining compliance with tuberculosis treatment in an urban environment, Tamatave, Madagascar Int J Tuberc Lung Dis 1998; 2(11):891–897.

13. Daniel OJ, Alausa OK. Default from tuberculosis treatment programin Samagu, Nigeria. Nigerian J Medicine2006; 15(1): 63-70.

14. Jaggarajamma K, Muniandy M, Chandrasekaran V, Thomas SG, Gopi PG, Santha T. Is migration a factor leading to default under RNTCP. Indian J Tuberc 2006;53:33-36.

15. Jaggarajamma K, Sudha G, Chandrasekaran V, Nirupa C, Thomas A, Santha T et al. Reasons for non-compliance among patients treated under revised national tuberculosis control programme(RNTCP), Tiruvallur district, South India. Indian J Tuberc 2007; 54:130-135.

16. Santha T, Garg R, Frieden TR, Chandrasekaran V, Subramani R, Gopi PG et al. Risk factors associated with default, failure and death among tuberculosis patient treated in a DOTS programme in Tiruvallur district, South India, 2000. Int J Tuberc Lung Dis. 2003 Feb;7(2):200-1.

17. Balasubramanian R, Garg R, Santha T, Gopi P, Subramani R, Chandrasekaran Vet al. Gender disparities in tuberculosis: report from a rural DOTS programme in south India. Int J Tuberc Lung Dis 2004; 8(3):323–332.

18. Jakubowiak WM, Bogorodskaya EM, Borisov ES, Danilova DI, Kourbatova EK. Risk factors associated with default among new pulmonary TB patients and social support in six Russian regions. Int J Tuberc Lung Dis 2007; 11(1):46– 53.

19. Chatterjee P, Banerjee B, Dutt D, Pati RR, Mullick AK. A complete evaluation of factors and reasons for defaulting in tuberculosis treatment in the state of West Bengal, Jharkhand and Arunachal Pradesh. Indian J Tuberc, 2003,50:17-22.

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23. Hasker E, Khodjikhanov M, Usarova S, Asamidinov U, Yuldashova U, Werf MJ. Default from tuberculosis treatment in Tashkent, Uzbekistan; Who are these defaulters and why do they default? BMC Infectious Diseases 2008; 8:97.

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25. Santha T, Garg R, Frieden TR, Chandrasekaran V, Subramani R, Gopi PG et al. Risk factors associated with default, failure and death among tuberculosis patient treated in a DOTS programme in Tiruvallur district, South India, 2000. Int J Tuberc Lung Dis. 2003 Feb;7(2):200-1.

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Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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