International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 7(8), April, 2015

Pages: 19-22

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COMPARATIVE EFFICACY OF SYNTOMETRINE VERSUS OXYTOCIN IN ACTIVE MANAGEMENT
OF THIRD STAGE OF LABOUR

Author: Arunadevi V.

Category: Healthcare

Abstract:Objective: Postpartum hemorrhage is a major obstetrical complication and one of the important but preventable causes of maternal morbidity and mortality. The aim of the study is to compare the efficacy of syntometrine versus oxytocin in the active management of third stage of labor in reducing the risk of PPH and other adverse third stage outcomes. Methodology: This is a randomized prospective comparative study conducted from September 2008 to August 2009 at the department of Obstetrics and Gynecology, Institute of Social Obstetrics and Govt. Kasturba Gandhi Hospital for Women and Children, Chennai, on 300 patients. The patients were assigned to 2 groups at random of 150 patients in each group. All pregnant women with singleton pregnancy of 20-35 years of age with no known risk factor for PPH were included. Exclusion criteria observed for patients with previous caesarean section, previous scarred uterus, multiple pregnancy, Cardiac patient, hepatic disorders, disorders of blood coagulation. The data was analyzed using t test and chi square test.
Results:
The mean blood loss in syntometrine group was 120ml and oxytocin group was 171ml. The difference of mean blood loss between two group was 51ml, which is statistically significant (p=0.000). Conclusion: It is concluded from this study that the use of syntometrine as part of routine AMTSL (Active Management of Third Stage of Labor) appears to be associated with a statistically significant reduction in mean blood loss when compared to Oxytocin.

Keywords: Syntometrine, Oxytocin, Third stage of labor, Postpartum hemorrhage

Full Text:

INTRODUCTION

Postpartum hemorrhage (PPH) is a nightmare to every obstetrician as it is sudden, frequently unpredicted and could be catastrophic. In the early decades of 20th century, PPH was the most common cause of maternal death (Thilaganathan et al1 – 1993). PPH is a major cause of maternal mortality worldwide with an overall prevalence of approximately 6%; Africa has the highest frequency of about 10.5%.2 PPH complicates 4% of vaginal deliveries and 6% of caesarean deliveries.3 About 14 million women suffer from severe PPH each year, and 140,000 of these die one in every 4 minutes.4

Excessive blood loss at delivery is defined as:

1. A loss in excess of 500 ml at vaginal delivery; 1000 ml at caesarean section or 1500ml at Caesarean hysterectomy (Prichard5 ).

2. 10% change in hematocrit between admission and postpartum period6

3. Need for an erythrocyte transfusion (Coomb)6 Primary PPH is loss of blood estimated to be > 500ml, from the genital tract, within 24hours of delivery 7. Secondary PPH is defined as abnormal bleeding from genital tract, from 24 hours after delivery until six weeks postpartum. Studies quote an incidence of PPH of around 5-10%.8,9

Etiological factors for PPH are as follows10:

1. Abnormalities of uterine contraction (Tone)

2. Retained products of conception (Tissue)

3. Genital tract abnormalities (Trauma)

4. Abnormalities of coagulation (Thrombin)

Uterine atony is the commonest of the numerous causes of PPH, accounting for 80-90% of cases.

Active Management of Third Stage of Labor (AMTSL) is an effective intervention to prevent PPH resulting from

uterine atony. AMTSL comprises the following series of interventions :

1. Administration of prophylactic uterotonic within 1 minute of delivery of the baby.

2. Controlled cord traction

3. Uterine massage after delivery of placenta.

AMTSL has been shown to reduce the incidence of PPH by approximately 60-70%.11,12,13 This study compares the efficacy of Syntometrine versus Oxytocin in AMTSL in reducing the risk of PPH.

MATERIALS AND METHODS

This randomized prospective case control study was conducted from September 2008 to August 2009, at Institute of Social Obstetrics and Govt. Kasturba Gandhi Hospital for Women and Children, Chennai on 300 patients, who were admitted in labor ward with no known risk factors for PPH. All patients included in the study delivered vaginally. The patients were assigned to 2 groups at random of 150 patients in each group. In group I, Syntometrine (5 IU Synthetic Oxytocin and 0.5 mg ergometrine maleate) and in Group 2 Oxytocin was administered i.m within 1 minute after delivery of the baby. This study was approved by Ethical Committee.

Inclusion Criteria:

1. Singleton pregnancy

2. No contraindication for oxytocin / syntometrine

3. No obstetric or other indication that could warrant abdominal delivery.

4. No known risk factor for PPH.

Exclusion Criteria:

1. Previous caesarean section

2. Previous scarred uterus

3. Multiple pregnancy

4. Cardiac patient

5. Hepatic disorders

6. Disorders of blood coagulationinal delivery

7. Past history of third stage complications

8. Known risk factor for PPH

9. Instrumental vaginal delivery

10. Absolute or relative risk factors for spontaneous vaginal delivery and hence posted for elective caesarean section.

Procedure: The delivery was effected with the patient at the edge of the table. Within 1 minute of delivery of the baby, either 10 units of injection oxytocin or 1 ampoule of syntometrine were given in a randomized order. The user will be unaware of the drug being given since all these drugs will be of the same color and ampoules will only be marked with appropriate numbers and no names will be mentioned. Once the placenta is removed, she was placed over a blood drape, which is a disposable, conical, graduated plastic collection bag. The amount of blood collected in the blood drape is measured. The average immeasurable blood loss due to episiotomy was taken as 50ml and the same is not included in the blood loss. Similarly when there was profuse bleeding following episiotomy, such patients were excluded from the study.

Results and Analysis
This study was commenced with 300 women and the outcome was analyzed using various parameters. The results were subjected to statistical analysis using the t test and chi square test. Most of patients in both groups were in age group of < 25 years. 70% of cases in group 1 and 62.7% of cases in group 2 were in age group < 25years. Only 5.3% in group 1 and 3.3% in group 2 were in age group > 30 years. 62.7% of women in group 1 and 60% of cases in group 2 were primigravida. 37.3% of cases in group 1 and 40% of cases in group 2 belonged to multigravida. All patients in our study group were booked cases, though they were selected at random basis. The mean blood loss in group 1 was 120ml and group 2 was 171 ml. The difference of mean blood loss between two group was 51ml, which is statistically significant ( p = 0.000). 2% of cases in group 2 and none of the case in group1 had blood transfusion, which is not statistically significant (0.082). None of the case in group 2 had side effects, whereas in group 1, 3.3% of cases developed adverse effects like nausea and vomiting. Only 2% of cases in group 2 had drop in hemoglobin level of 0.7 to 1 grams percent after delivery. The mean birth weight of the baby in both groups was 3.1 Kg.

Discussion

The synthetic form of the octapeptide, oxytocin is commercially available as Syntocinon or Pitocinon. It increases the frequency and strength of uterine contraction and augments retraction of uterus. Syntometrine injection is a clear, colorless solution and contains maleic acid as a buffer, pH3.2. Syntometrine combines the rapid uterine action of oxytocin with sustained uterotonic effect of ergometrine. The uterotonic effect of syntometrine lasts for several hours compared with only ½ to 1 hour when oxytocin is given alone.

When syntometrine is stored for prolonged periods of time, it must be kept at between 2 and 8o C and protected from light ( Hozerzeil et al14, 1994). Oxytocin is more stable in tropical climates. The efficacy of syntometrine has been shown to be significantly reduced when it is stored in a suboptimal environment (Chua15 et al 1993). The review by McDonald16 et al comparing syntometrine and oxytocin revealed that the use of intramuscular syntometrine was associated with reduced risk of PPH with a summary odds ratio of 0.74 (95% CI – 0.85) regardless of the dose of oxytocin used. Docherty and Hooper17 (1981) reported that oxytocin was associated with a 40% increase in mean blood loss, but absolute rate of PPH was not stated. Yuen et al18 (1995) reported a 40% reduction in risk of PPH and the need for repeated oxytocin injections in the syntometrine group compared to oxytocin and side effects were uncommon in both groups. The overall comparison of 10 units of intramuscular oxytocin with syntometrine still favors syntometrine. Edgardo Abalos19 stated that the use of syntometrine as part of AMTSL is associated with significant reduction in the incidence of PPH (blood loss 750 ml) irrespective of the dose. Since the prevention of maternal death from PPH is considered a fair price to pay for experiencing nausea, vomiting and hypertension ( Dwyer20 1994), syntometrine is now routinely used in most developed countries.

Conclusion

It is sad that inspite of tremendous advancement in medical science, women still die of PPH even in the developed countries. Active management should be the routine management of choice for women expecting to deliver a baby by vaginal route in a health care facility. The choice of drug depends on cost, facilities for storage and refrigeration, availability of trained personnel and assessment of trade off between benefits and side effects. The RCOG in the UK recommends that the oxytocics be offered routinely in the management of the third stage of labour in all women, as their administration reduces the risk of PPH by about 60%. The combination preparation syntometrine as part of routine AMTSL appears to be associated with a statistically significant reduction in risk of PPH, compared to oxytocin.

ABBREVIATIONS

PPH – Post Partum Hemorrhage

AMTSL – Active Management of Third Stage of Labour

Acknowledgement

Author acknowledges the enormous help received from the scholars whose article have been cited and incorporated in references. Author is also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this articles has been reviewed and discussed.

 

References:

1. Thilaganathan B et al, Management of the third stage of labour in women at low risk of postpartum hemorrhage. Eur J. Obstet Gynecol Reprod Biol. 1993. Jan: 48 (1): 19 –22.

2. Carroli G, Cuesta C, Abalos E, et al. Epidemiology of postpartum haemorrhage: a systematic review. Best Pract Res Clin Obstet Gynaecol 2008; 22: 999–1012.

3. Mousa H, Alffirevic Z. Treatment for primary PPH (Cochrane Review). The Cochrane Library, Vol. I. Oxford : Update software;2003.

4. Abouzahr C. Global burden of maternal death and disability. Br Med Bull. 2003;67: 1–11.

5. Pritchard JA, Baldwin RM, Dickey JC, Wiggins KM. Blood volume changes in pregnancy and puerperium. Am J Obstet Gynecol 1962; 84 (10); 1271–82.

6. Coombs CA, Murphy EL, Laros RK. Factors associated with postpartum hemorrhage with vaginal birth. Obstet Gynecol 1991; 69–76.

7. Prevention and management of postpartum hemorrhage; Royal College of Obstetricians and Gynaecologists (May 2009 with revision April 2011).

8. Fullerton G, Danielian PJ, Bhattacharya S: Outcomes of pregnancy following postpartum haemorrhage. BJOG. 2013 Apr 120 (5); 621–7.

9. Carroli G, Cuesta C, Abalos E, et al: Epidemiology of postpartum heamorrhage a systematic review. Best Pract Research Clinic Obstet Gynaecol. 2008 Dec; 22 (6); 999– 1012.

10. Schuurmans N. Mackinnon C, Lane C, Etches D. Prevention and Management of postpartum Hemorrhage. SOGCC. Clinical Practice Guidelines. No.88, April 2000.

11. Prevention and treatment of post partum haemorrhage : new advances for low resources settings. Joint – Statement. International Confederation of Midwives (ICM) International Federation of Gynaecology and Obstetrics (FIGO).

12. Prendiville WJP, Elbourne D, McDonald SJ. Active versus expectant management in the third stage of labour. Cochrane Database of Systematic Reviews 2009; Issue 3.

13. WHO recommendations for the prevention of postpartum haemorrhage. Geneva: World Health Organization; 2007.

14. Hozerzeil HV, Walker GJA and De Goeje MJ (1994) Oxytocin is more stable in tropical countries.

15. Chua, S. Arul Kumaran, S. Adaikan, G. et al., (1993). The effect of oxytocin stored at high temperatures on postpartum uterine activity. Br. J. Obstet, Gynaecol, 100,874–875.

16. McDonald S, Prendville WJ, Elbourne D, Prophylactic syntometrine versus oxytocin for delivery of the placenta. The Cochrane Database of Systematic reviews, Volume 1, 2001.

17. Docherty PW, Hooper M, Choice of an oxytocic agent for routine at delivery. J Obstet Gynaecol 1981; 2: 60.

18. Yuen PM, Chan NST, Yim SF, Chang AMZ,. A randomized double blind comparison of syntometrine and syntocinon in the management of third stage of labor. Br. J Obstet and Gynaecol 1995; 102377–380.

19. Ebardo Abalos. Evidence summary, Different interventions have been proposed for the management of third stage of labour. RHL. 20. Dwyer N (1994) Nausea is a fair price for preventing hemorrhage Br. Med J 308, 59.

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

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A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
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A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
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A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
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List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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