International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 13(2), January, 2021

Pages: 106-112

Date of Publication: 16-Jan-2021


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An overview of the Implant Therapy: The Esthetic Approach

Author: Kashish Mangal, Mithilesh M. Dhamande, Seema Sathe, Surekha Godbole, Rupali M. Patel

Category: Healthcare

Abstract:Many have mastered the skills of implant placement, but the art of rehabilitating the patient with anaesthetic prosthesis is the most important aspect of the treatment. While dealing with implants placed in the anterior region of the oral cavity in patients which in a way can be termed as the limelight area for esthetics, incorporating various factors for esthetics become imperative. This article aims to concise the majority of these factors under one umbrella. For this article, a thorough online search on this topic was carried out for collection and evaluation of available data. Before the surgery, the patient should be thoroughly evaluated using appropriate records like study models and necessary investigations like radiographs and CBCT scan should be obtained to assist in appropriate planning of the case. The patient's soft and hard tissue profile has to be evaluated, any discrepancy in which should be suitably addressed. After the pre-surgical evaluation, the technique of implant placement should be finalised by the patient's clinical conditions and requirements. The implant should be placed in an ideal manner to create near to natural esthetic profile. Any aberrations in the soft tissue occurring should also be anticipated and managed to reduce the number of surgeries required in the creation of the esthetic appearance. Once the placement has been done a suitable abutment should be selected and the entire focus should be given to creating a natural emergence profile for the future implant prosthesis. The result should be a natural life-like esthetic profile of the patient.

Keywords: Implant esthetics, Provisionalization, Emergence profile, Implant position

Full Text:

Introduction

With the increase in technological advancement, a good number of population has now become more aware regarding the available dental treatments and its importance. Not only this but the significance of teeth in the esthetics and appearance of a person has also been more accepted and understood by people. When a patient loses their anterior teeth, the most preferred option by patients has been fixed prosthesis because of various reasons out of which esthetics is prime.

Esthetics can be defined as “the theory and philosophy that deal with beauty and the beautiful, especially concerning the appearance of a dental restoration, as achieved through its form and/or colour; those subjective and objective elements and principles underlying the beauty and attractiveness of an object, design, or principle.1 This becomes truer when the clinician is dealing with the anterior zone which is the prime esthetic focal point of any person.

Dental implants were first introduced by Brånemark in the 1900s.2 Since then there have been countless advancements in this treatment modality ranging from its type, design, material as well as associated techniques. Currently, the market is flooded with a huge array of options available.3 A few of these have specifically been designed keeping the esthetic demands of the treatment.4-6 Though awareness in the population about implants as the preferred treatment is limited but the willingness to know more has been reported.9

Many have mastered the skills of implant placement, but the art of rehabilitating the patient with anaesthetic prosthesis is the most important aspect of the treatment. Detailed information regarding managing the anterior esthetics specifically for implant-retained fixed dental prosthesis [FDP] is relatively less. The existent difference between natural teeth and a dental implant governs various factors which need an additional consideration of anterior implant-retained FDP.2,10,11 This article deals with the implant esthetics and factors associated with it while specifically dealing with the anterior zone. For ease of clinical correlation and understanding, three different phases of the treatment have been identified with their respective imperative factors to be considered for optimum implant esthetics (Table 1).

Pre-Surgical Phase

When a patient enters the clinic with the expectation of rehabilitating his lost anterior teeth, the best treatment that can be given to him starts with an impeccable treatment planning before implant placement. It includes –

  • Study Model Evaluation

  • Radiographic Evaluation

  • Soft & Hard Tissue Evaluation7,8

Study Model Evaluation

The study models in any and every prosthodontic treatment are indispensable. These important diagnostic tools enhance the predictability of the treatment & enabling proper treatment planning with a 3D working representation of the patient to the clinician.13 This overall visualization of the patient’s oral cavity helps in planning a holistic treatment for the patient.

The analysis of obtained models can give the clinician a wide range of information including the occlusal & arch relation, interarch space, number & position of adjacent teeth, appreciation of the edentulous ridge as well as planning of future implant placements to be done.

Radiographic Evaluation

Bone quality governs the success of implants. It is a primary factor in successful osseointegration of implants. Before the decision of implant placement is made, it is always imperative to assess the bone condition in which the said treatment is planned to estimate the prognosis. This bone quality is assessed with the help of roentgenographs or radiographs.

With the help of Cone Beam Computed Tomography (CBCT), we can now have a very accurate idea of the bony conditions which the clinician might encounter.14,15Software these days come along with additional features of assessing the Hounsfield units of the imaged bone which when compared with the Mischclassification for bone can give a precise idea for the prognosis of the treatment.9,10

Soft & Hard Tissue Evaluation

Esthetics is a harmony which exists between the teeth and its surrounding hard and soft tissues. Therefore, assessment of the adjacent structures is also necessary. Firstly, the gingival biotype i.e. thickness of the gingiva in faciopalatal/ faciolingual direction is to be assessed. It can be divided into two types- thin and scalloped or thick and flat. When the gingiva measures less than 1.5mm it is deemed as thin and scalloped biotype and when it has a dimension more than 2mm it is called thick and flat. Normal thickness of gingiva ranges from 1.5-2 mm. An unfortunate chance of visibility of an unesthetic titanium ‘shadow’ may be seen with thin biotype along with increased vulnerability for gingival recession. Thus, various esthetic prosthetic implant options like esthetic abutments or different implant placement technique or varied implant design might be considered.

Secondly, an assessment of the keratinized band of gingiva has to be made. A minimum requirement of 2 mm has been suggested for optimum peri-implant esthetics. Thirdly, the available bone height and width has to be checked in absence of which various grafting and augmentation techniques like vertical augmentation, en bloc grafting, particulate grafting, distraction osteogenesis. might have to be employed.16,17

Surgical Phase

Under this head, first comes the evaluation of best possible esthetic implant placement modality. After it, the ideal implant placement has to be ensured by the implantologist following which comes the management of soft tissue.11,12

Available Treatment Modalities

The ultimate aim of a treatment offered by any dentist is to give the patient the best possible results. With the inputs of various creative and great minds over the years, now we have a variety of treatment modalities to choose from as per the patient’s requirement. The two modalities which stand out in this are – Guided implant surgery and Immediate implant placement. These both techniques have been advised and reported with better results when dealing with implant placement in the patient’s esthetic zone.

Both of these techniques work best when applied together but can also be employed separately. Guided implant surgery refers to implant placement with the help of a custom made surgical stent for the patient with the help of their CBCT scans and respective analysis made on the scan. The data is then processed via computer-aided designing and computer-aided manufacturing (CAD-CAM) machinery to fabricate a replica of the image assessment and planned implant. The most important advantage that this technique offers is the precise implant placement in the patient and thus optimum esthetics.18-20 Immediate implant placement works best when we are dealing with the anterior zone provided the appropriate method of temporization is used. This provides the patient with not only an immediate replacement and thus protect them from any social or personal awkwardness regarding edentulousness but also the extracted tooth provides optimum guidance for optimum implant placement.21,22

Ideal Implant Positioning

Another important factor to consider while ensuring the best possible esthetics for a patient is the appropriate implant placement. A faulty placement may not only lead to esthetic but also prosthetic complications.

  1. Mesio-distal positioning

The implant should be placed with at least 1.5mm of the distance between the implant and adjacent teeth on each side. In cases of multiple implant placement, a minimum of 3mm inter-implant distance should be maintained (Figure 1).23

  1.  Labio-palatal positioning

This dictates the angulation at which the implant will be placed in the alveolar bone. The labio-palatal positioning holds utmost importance when dealing with anterior zone since it helps in developing the emergence profile of future implant prosthesis. The ideal positioning of the implant in this direction is advised to be following the facial contours of the adjacent teeth. A minimum of 1-1.5mm of buccal bone and 0.8mm of palatal bone should be spared while placing the implant (Figure 2). 24

Not only the amount of bone but the type of future implant prosthesis which is planned also dictates the labio-palatal positioning of the implant. It has been advised that if the prosthesis has to be cement-retained then the placement has to exactly in the centre of the long axis of the said prosthesis. When a screw-retained prosthesis is planned, the implant may have to be positioned slightly palatal to the long axis of the prosthesis to ensure palatal access to the screw channel. An improper implant placement or a too buccal placement may lead to inadequate buccal bone present to envelope the implant. This may further result in severe complications like dehiscence or fenestrations.11

  1. Apico-incisal Positioning

An implant placed rightly in the axial or apical-incisal direction will give the clinician sufficient space to develop an adequate emergence profile for the future implant prosthesis. It has been suggested that the implant ideally should be placed 2-3mm apically to an imaginary line connecting the deepest portions or the zenith of gingival contours of the adjacent teeth. When the natural adjacent landmarks are missing and multiple implants are to be placed then the implant head can be positioned at the alveolar crest within the circumference of the tooth to be restored. The 2-3mm of pico-incisal distance will give the clinician sufficient space around the implant, otherwise called a running room, within which the contours of restoration can be developed (Figure 3).12-14

It is an obvious fact that the cross-sectional diameter of a natural tooth and the head of an implant has a huge variation. To compensate this & provide the patient with a near to natural esthetics, this running room is essential. In this, the clinician can gradually increase the bulk of material to create optimum peri-implant esthetics.15

Soft Tissue Management

As rightly said by Professor Dr. Jan Lindhe “The bone sets the tone, the soft tissue is the issue”, dealing with the peri-implant soft tissue for a complete esthetic appearance is of great significance. The major value here has to be given to the development of suitable interdental papilla, the absence of which may lead to the highly unesthetic black triangles. If the implant were to be placed appropriately in its apical-coronal direction, then according to Tarnow, with 5mm of the distance between the crest of the bone and contact point of teeth and prosthesis should observe a 100% papilla fill. As the distance increases a reduction in papillary fill is observed which may further complicate the situation and require surgical or prosthetic intervention for correction.25–28

Post-surgical Phase

After the implant has been placed, and it is the time for restoration, the post-surgical management of implant esthetics come into the picture. In this, the primary focus will be on professionalization, development of emergence profile, abutment selection followed by the definitive prosthesis and follow-up.

  1. Provisionalization

Provisionalization or temporisation refers to rehabilitating the patient with a short-lived treatment option until definitive restoration can be put into its place.29 They help not only in improving the quality of life for the patient undergoing implant therapy by enhancing his esthetics but also serves as a template for designing the definitive prosthesis. The provisional prosthesis can be given soon after the tooth extraction or during the socket healing and site development. It can also be utilized before implant placement or during the phases of osseointegrationor after the second stage surgery. In such case, the provisional prosthesis will help in supporting the soft tissue to build an appropriate emergence profile and help in assessment of esthetics and phonetics prior to fabrication of the definitive restoration.30

Broadly, provisional restorations can be classified as removable or fixed. Under the umbrella of temporary prosthesis, the clinician has various options like an existing prosthesis that the patient already uses or a removable partial denture, a vacuum formed retainer, a chairside or laboratory made resin bonded bridge,conventional FDP, provisional prosthesis supported by immediately loaded transitional implants or implant-supported provisional prosthesis. The choice of provisional prosthesis should be made considering the type of treatment modality planned. For example, in cases where the surgical site has been modified with augmentation or grafting which necessitated a longer unhindered healing period, a provisional prosthesis which can withstand for the prescribed duration without hampering the healing and also enable modifications as and when required should be preferred. In cases of immediate implant placement, if an immediate temporary restoration/ prosthesis is planned, then it should be constructed such that support to the peri-implant tissue is provided. With this, the provisional prosthesis would help in preserving the already existing soft tissue curtain of the extracted natural tooth.4,30-31

  1. Development of Emergence Profile

Emergence profile is the contour of the implant restoration as it emerges from the gingiva. Creating a natural emergence profile holds utmost importance in implant esthetics. This can be done with ideal/ optimum implant placement and usage of proper temporary restoration for the patient.32-33 In optimal intraoral conditions where no major corrective procedures are required, the provisional prosthesis can be employed for the creation of an almost natural emergence profile.30The temporary restoration aids by the virtue of its diameter which is gradually increased beneath the gingival envelope, in other words within the running room. If the apical-incisal positioning of the implant is faulty resulting in an inadequate running room, the emergence profile of the restoration may be compromised.

Every restoration within this running room should possess sub-critical and critical contours (Figure 4). These contours have to be incorporated in the prosthesis as per the requirement of the patient’s peri-implant conditions. Critical contour refers to the area of implant prosthesis and an underlying abutment which is immediately apical to the gingival margin of the restoration. The facial/labial profile of the critical contour plays a significant role in the location of the zenith of the associated gingival curtain which directly affects the apparent clinical length of the crown. Also, the interproximal profile of critical contour governs the shape of the prosthesis (triangular/ square). Modification in critical contour can affect the level of gingival zenithlabially.34

The second is sub-critical contour which exists only when an optimum running room has been given. This is the area of implant prosthesis which lies immediately coronal to the implant-abutment interface. Modification in the profile of this contour [convex, concave or flat] can have a significant effect on the overlying gingival envelope. If made convex it will support the gingival curtain, the concave profile may help in gaining increased tissue volume and in ideal conditions it can be maintained flat. The interproximal modification of this subcritical contour is said to help in enhancing the papilla fill inter proximally up to 0.5 –  1 mm.35

  1. Abutment Selection

The future of the prosthesis depends on the type of abutment selected. Currently, numerous options are available for the clinician ranging from different materials to different angulations and types of retention. Based on the type of retention, screw or cement-retained abutments may be chosen. Both of them have respective pros and cons, but their selection is also relative to the implant placement and vice-versa as stated earlier. If the abutment screw channel arises on the labial aspect of the prosthesis, then it will require further management to create an esthetic appearance which may not be completely acceptable to the patient.

In cases where prior soft tissue evaluation was done and the patient had a thin gingival biotype with a high probability of a titanium shadow display, esthetic implant options will have to be considered.36 This is also true in cases whereas a result of improper implant placement titanium hue is visible. With the recent advances in biomaterials, there are diverse options available to handle such situations. These include Zirconia abutments, hybrid abutments, polyetheretherketone (PEEK) abutments etc.37-39

If the patient presents with an improperly placed implant or an implant with abnormal angulations, then utilization of angulated abutments or customized abutments may be required to fulfil the esthetic requirements of the patient. Variety of pre-angulated abutments are available with manufacturers these days ranging from 17 degrees to 35 degrees. But when the favourable esthetic profile cannot be established with the angulated abutments as well, the clinician might have to opt for customized abutments. Here, the options include castable abutments as well as the newer CAD-CAM abutments which widens the horizons with different biomaterials to be milled using various types of machinery for accurate fit and esthetics.34,40

Definitive prosthesis and Follow-up

The task of construction of anaesthetic definitive or final restoration for anterior implants becomes much easier when appropriate temporization has already been employed. This provisional restoration, after thorough assessment for esthetics which includes the creation of emergence profile, phonetics and function, could directly be replicated to form the definitive restoration. With the technological benefit of CAD-CAM, this provisional restoration can directly be scanned and a replica of the same can be obtained. This helps the clinician by eliminating the errors which might occur due to multiple impression, duplication and laboratory procedures.26

After the definitive prosthesis has been delivered, the patient can be evaluated for the esthetics and function imparted by the restoration by using various scales and indices available. With the help of such indices along with patient satisfaction and clinician’s evaluation, the success of prosthesis and thus the treatment can be verified and justified.

Conclusion

The rehabilitation of the esthetic zone by implant-retained FDP is one of the most demanding and complex treatments due to the necessity to obtain an optimum esthetic result. Through osseointegration, restoration of function and soft and hard tissue esthetics dictate implant success, the patient's satisfaction is a key element of the success of implant therapy. With the concurrent paradigm shift in the approach of dental implantology making it more prosthetically driven, the necessity of a synergistic harmonious interdisciplinary approach between implant placement, soft tissue management and the prosthetic rehabilitation holds the key towards a happy and satisfied patient and clinician. To achieve this, a treatment governed by the guidelines for esthetic rehabilitation, specifically designed for implant rehabilitation should be imparted to the patient. This article outlines these guidelines with details about their clinical implication to help clinicians decide the best treatment course for the patient.

Conflict of interest: Nil

Acknowledgment: Authors acknowledge the immense help received from the scholars whose articles are cited and included in references to this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

Figure 1 : Illustration showing mesiodistal positioning of implant. a= 1.5mm distance between implant and adjacent teeth; b= 3 mm inter-implant distance.

Figure 2: Illustration showing labio-palatal positioning of the implant. The green line denotes the level of implant head, the blue line represents the natural labial contour of natural teeth. a) Optimum space is present between the implant head and tooth contour whereas in b) implant is placed too close to the buccal contour and c) too much distance exists between the labial contour and implant making it difficult to rehabilitate with good esthetics.

Figure 3 : Illustration depicting correct apico-coronal implant position. Ideally it should be placed 2-3mm beneath the gingival zenith to allow for adequate running room for prosthetic build-up.

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Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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