International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 8(7), April, 2016

Pages: 04-07

Date of Publication: 12-Apr-2016


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DOES BODY MASS INDEX EFFECT NERVE CONDUCTION? A CROSS SECTIONAL STUDY

Author: Vineeta Chadha, Surendra S. Shivalkar

Category: Healthcare

Abstract:Aim: Body mass index (BMI) is an important parameter in gauging adiposity and obesity. Many studies have shown higher incidence of cardiovascular diseases especially coronary artery diseases in population with BMI greater than 25. (1) Studies also reveal median and ulnar nerve compression associated with an increasing incidence of higher BMI. (2) This study is an attempt to establish a relationship between median nerve conduction parameters and BMI in a population group from a metropolitan city in urban India. Methodology: In the present study the effect of Body Mass Index (BMI) on Median nerve motor and sensory conduction latency, amplitude and velocity was analysed in 90 healthy people in the age group of 18-30 years. Standardized protocol was followed while performing nerve conduction study in all the subjects. Results: This study shows that sensory nerve conduction amplitude decreases significantly with increase in BMI whereas the effect on other parameters is non-significant. Conclusion: This could be attributed to attenuation in conduction current by thicker subcutaneous tissue in persons with higher BMI. Median nerve latency and conduction velocity do not show significant decrease. This could be due to the fact that speed of conduction is same in the fastest conducting fibres irrespective of the adiposity..

Keywords: Nerve conduction velocity, Nerve conduction latency, Nerve conduction amplitude, Body mass index, Median nerve

Full Text:

INTRODUCTION
Nerve conduction study is used in the diagnosis of focal or diffuse peripheral neuropathies. Various study parameters are used to differentiate between the types of neuropathies and to know the extent and distribution of lesion. (3) Nerve conduction studies (NCS) are in turn affected by gender, age, height, weight and temperature. (4) Past studies have shown that high BMI is a risk factor for carpel tunnel syndrome and variation of body mass index (BMI) from normal is a risk factor for ulnar neuropathy at elbow. (2) Negative correlation has been shown between BMI and sensory nerve action potential amplitude (5).

BMI is an important factor taken into consideration while assessing peripheral neuropathy in diabetic patients. (6) Influence of BMI on nerve conduction velocity has been evaluated, however, majority of these studies are based on Caucasian subjects. (7) This study is aimed at deriving normative reference data on Indian population that closely relates to the demographic profile of the patients being studied. It has been hypothesized in this study that high BMI leads to decrease in nerve conduction velocity, increase in latency and decrease in amplitude of nerve conduction.

MATERIALS AND METHODS
The study was conducted in a teaching college and hospital in Mumbai with prior permission of the ethical committee on 90 healthy volunteers in the age group of 18-30yrs. Through relevant history and neurological examination, subjects with medical conditions (Diabetes Mellitus, Thyroid Disorders, Neuromuscular disorders, Drug Abuse and Chronic Alcohol Abuse) or on drugs (Antiretroviral, Antitubercular) that could affect nerve conduction were excluded. A brief explanation of the procedure was given to the subjects and voluntary informed consent was taken. Height and weight of each subject was recorded and BMI was calculated as weight (kg) divided by height (m) squared.

The study group was divided into 3 depending upon the value of BMI (BMI25). The amplitude, latency and conduction velocity were measured for Compound Muscle Action Potential (CMAP) as well as Sensory Nerve Action Potential (SNAP) component of median nerve prospectively using NEURO – MEP – NET EMG/NCV/EP (NEUROSOFT) equipment according to standard protocol and settings at a room temperature of between 24-30o C. (8, 9) For motor nerve conduction study the low frequency filter was set at 2 Hz and high frequency filter at 10 kHz. For sensory nerve conduction study the low frequency filter was set at 5 Hz and high frequency filter at 3 kHz.

The sweep speed was set at 2 milliseconds/division. (8, 9) Motor NCS requires stimulation of a nerve while recording from a muscle innervated by that nerve, whereas sensory NCS require stimulating a mixed nerve while recording from a mixed or cutaneous nerve. (10) Median motor and sensory nerve conduction velocity were recorded as described by Mishra and Kalitha. (8) Recording electrode was placed on the motor point of Abductor Pollicis Brevis, reference electrode 3cm distal to recording electrode and ground electrode was placed on dorsum of the hand for Median motor nerve conduction parameters.

Similarly median sensory conduction was performed orthodromically with respective electrodes placed on appropriate sites. (8) Conduction velocity, latency and amplitude of the median nerve were taken for analysis. ANOVA was used to analyse the effect of BMI on nerve conduction velocity, latency and amplitude. Pearson’s correlation coefficient (r) was used for finding correlation between BMI and Nerve conduction velocity, latency and amplitude.

Observations and Results
Data was statistically analyzed using appropriate tests after adjusting for age and sex. With increasing BMI, there was a decrease in amplitude of sensory median nerve which was statistically significant. No correlation was noted between BMI and nerve conduction velocity and latency. Motor and sensory nerve conduction amplitudes correlated significantly (P < or = 0.05) with BMI.

DISCUSSION In this study, effect of body mass index (BMI) on nerve conduction parameters for median nerve was evaluated. Results were statistically analyzed and normal values for median nerve conduction in healthy Indian population calculated. The findings of this study are similar to, Buschbacher RM et al (7) who showed that sensory and mixed nerve amplitudes correlated significantly (p < or = 0.01) with BMI for all the tested nerves. This study shows correlation between sensory amplitudes but not with mixed nerve amplitudes. Mean of amplitudes in subjects with higher BMI (obese) was less than in thin subjects.

This could be attributed to the fact that thicker subcutaneous tissue in persons with higher BMI causes amplitude attenuation. Hasanzadeh P et al. also showed that sensory amplitudes decrease but motor amplitudes are spared with increasing BMI. (5) This could be due to the thousand times rise in motor amplitude voltage (millivolts) as compared to sensory amplitude (microvolt). Also, Buschbacher RM et al (7) did not observe significant association of decrease in latency with higher BMI for median nerve which was similar to the findings in our study.

This observation might be due to the fact that median nerve being deeper is not much dependent on subcutaneous fat thermal insulation to maintain perineural temperature and thus individuals with various height and weights or BMI have almost similar temperatures around this nerve causing similar latent periods of conduction. They also reported no correlation between BMI and nerve conduction velocity, latency or most of the other motor and sensory parameters. This could be attributed to the fact that the speed of conduction is equal in fastest fibres in obese and thin individuals. The findings of this study are in contrast with Awang MS et al (10) who showed decrease in conduction velocity in median nerve with increasing BMI. In this study no significant increase or decrease in sensory and motor median nerve conduction velocity was found. The findings of this study are also in contrast with Baqai HZ et al (11) where no effect of BMI on nerve conduction parameters was reported. The present study also found greater influence of BMI on sensory nerve conduction as compared to motor nerve conduction studies. This was similar to the findings reported by Buschbacher RM (7) and Pawar et al (12).

Vessey et al. described an increasing risk of developing Carpel tunnel syndrome in women with higher BMI.(13) Kouyoumdjian et al. demonstrated in Brazilian population, that increasing BMI is correlated with a higher relative risk for developing compressive neuropathy. (14) Werner et al. found that the likelihood of developing median mononeuropathy at the wrist was 2.5 times higher in obese individuals (BMI > 29) than the slender ones (BMI < 20). (15) Thus there is a causal relationship between changed median nerve conduction parameters and increased BMI causing neuropathies which could be due to increased hydrostatic pressure or fatty tissue within the carpal tunnel in obese individuals. (15) Therefore the correlation between increased BMI and lower median sensory nerve amplitudes should be taken into account in clinical practice.

Another aspect is the increase in production of adipokines like plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNF-α), resistin, leptin, and adiponectin in subjects with high BMI. (16) Adipocytes induce production of reactive oxygen species initiating the process of oxidative stress. (17) Diminished activity of antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase due to increasing adiposity could be implicated in causing free radical injury. Hence it is highly recommended that studies be conducted on molecular level to establish a relationship between nerve conduction parameters, increasing level of adipokines and oxidative stress.

CONCLUSION In conclusion this study demonstrates that most of the parameters of nerve conduction study are not significantly associated with BMI. However the correlation between increased BMI and decreasing sensory nerve action potential amplitudes should be considered while testing for carpel tunnel syndrome and neuropathies in obese subjects.

ACKNOWLEDGEMENT Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. Source of Funding: None Conflict of interest: None stated

References:

1. Romero-Corral A, Montori V M, Somers V K, Korinek J, Thomas R J, Allison T G, Mookadam F, Lopez-Jimenez F. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review of cohort studies. Lancet. 2006 Aug 19;368(9536):666-78.

2. Landau ME, Barher KC, Campbell WW. Effect of body mass index on ulnar nerve conduction velocity, ulnar neuropathy at elbow and carpal tunnel syndrome. Muscle Nerve 2005; 32(3): 360–363.

3. Kimura J. Principles and pitfalls of nerve conduction studies. Ann Neurol 1984; 16: 415-429.

4. Chi-Ren Huang, Wen-Neng Chang, Hsueh-Wen Chang, NaiWen Tsai, and Cheng-Hsien; Effects of Age, Gender, Height, and Weight on Late Responses and Nerve Conduction Study Parameters; Lu Acta Neurol Taiwan 2009;18:242-249

5. Hasanzadeh P, Oveisgharan S, Sedighi N, Nafissi S. Effect of skin thickness on sensory nerve action potential amplitude. Clin Neurophysiol 2008; 119(8): 1824–1828.

6. Xuan Kong, Eugene A. Lesser, Frisso A. Potts, Shai N. Gozani. Utilization of Nerve Conduction Studies for the Diagnosis of Polyneuropathy in Patients with Diabetes: A Retrospective Analysis of a Large Patient Series. J Diabetes Sci Technol. 2008 March; 2(2): 268–274.

7. Buschbacher RM. Body mass index effect on common nerve conduction study measurements.Muscla Nerve, 1998 Nov; 21(11):1398-404

8. Misra U K, Kalita J. Clinical Neurophysiology, 2nd Edition: 1-128.

9. Misulis KE, Head TC. Nerve conduction study and electromyography. In: Pioli SF, editors. Essentials of Clinical Neurophysiology. 3rd Ed. Burlington: Butterworth-Heinemann; 2003. p.129-144.

10. Awang MS, Abdul lah JM, Abdul lah MR, Tharakan J, Prasad A, Husin ZA, Hussin AM, Tahir A, Razak SA. Nerve conduction study among healthy Malays . The influence of age, height, and body mass index on Median, ulnar , common peroneal and sural nerves. Malaysian Journal of Medical Sciences 2006; 13(2): 19–23.

11. Baqai HZ, Tariq M, Din AMU, Khawaja I, Irshad M. Sural nerve conduction; Age related variation studies in our normal population. The Professional 2001; 08(04): 439–444.

12. Sachin M. Pawar, Avinash B. Taksande and Ramji Singh. Effect of body mass index on parameters of nerve conduction study in Indian population. Indian J Physiol Pharmacol 2012; 56(1) : 88–93

13. Vessey MP, Villard-Mackintosh L, Yeates D. Epidemiology of carpal tunnel syndrome in women of childbearing age:findings in a large cohort study. Int J Epidemiol 1990;19:655-659.

14. Joao Aris Kouyoumdjian, Maria Da Penha Ananias Morita, Paulo Ricardo Fernando Rocha, Rafael Carlos Miranda, Gustavo Maciel Gouveia. Body Mass Index And Carpal Tunnel Syndrome. Arq Neuropsiquiatr 2000;58(2-A):252-256

15. Werner RA, Albers JW, Franzblau A, Armstrong TJ. The relationship between body mass index and the diagnosis of carpal tunnel syndrome. Muscle Nerve 1994;17:632-636.

16. Fonseca-Alaniz, M.H.; Takada, J.; Alonso-Vale, M.I.; Lima, F.B. Adipose tissue as an endocrine organ: From theory to practice. J. Pediatr. 2007, 83 (Suppl. 5), S192–S203.

17. Alba Fernandez-Sanchez, Eduardo Madrigal-Santillan, Mirandeli Bautista, Jaime Esquivel-Soto, Angel Morales-Gonzalez, Cesar Esquivel-Chirino, Irene Durante-Montiel, Graciela Sanchez-Rivera, Carmen Valadez-Vega and Jose A. MoralesGonzalez. Inflammation, Oxidative Stress, and Obesity. Int. J. Mol. Sci. 2011, 12, 3117-3132.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
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A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
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A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
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A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
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A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
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A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
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A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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