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IJCRR - 8(21), November, 2016

Pages: 12-18

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OBJECTIVE ASSESSMENT OF PHYSIOLOGIC AGEING CHANGES BY PATTERN REVERSAL VISUAL EVOKED POTENTIALS

Author: Sangeeta Gupta, Gaurav Gupta

Category: Healthcare

Abstract:Background: Impairment of visual information processing is one of the profound physiologic effects of ageing. Visual evoked potentials can record electrophysiological alterations in the visual pathways that can occur due to ageing and the nature of the impact in the older adults can be evaluated. Rapidly increasing size of the older population further emphasizes the acquisition of the data for this proportion of population optimizing the clinical evaluation in this group.
Methods: Pattern-reversal visual evoked potentials (PRVEP) were recorded in 120 healthy subjects in the age-group of 20-80 years (60 males and 60 females). Mean P100 latencies and N75-P100 amplitudes were compared in different age-groups by one way ANOVA. Correlations of latencies and amplitudes with age were performed using Pearson correlation coefficient. Gender differences were studied by unpaired t test. P value< 0.05 was considered as statistically significant.
Results: Mean P100 latency increased with age (both eyes) (both the sexes) with statistical significance (p< 0.01) while mean N75-P100 amplitude did not vary significantly (p>0.05). Males exhibited increased mean P100 latency as compared to females (p< 0.0001) while increased mean N75-P100 amplitudes were recorded in females (P< 0.0001).
Conclusion: Prolonged PRVEP P100 latency with age reflects electrophysiological alterations in visual pathways. Males demonstrate significant ageing changes earlier in life than females. Gender differences reveal increased P100 latency in males and increased N75-P100 amplitude in females in young as well as older adults. PRVEPs are useful objective measures to investigate the involvement of neural elements of visual system in the elderly individuals.

Keywords: Visual evoked potentials, Ageing, P100 latency, N 75-P100 amplitude

Full Text:

Introduction

Physiologic ageing, a universal and natural phenomenon of gradual deterioration of physiologic functions with age has been of particular interest to the researchers studying the mechanism of ageing and age-related diseases.The effects of ageing are widespread in the body with brain as no exception. Slowing in visual processing speed is a common characteristic of ageing and has been a well-established phenomenon.1Visual abilities decline during normal (non-pathological) ageing. Many physiologic changes in the vision during ageing often represent same continuum as those due to disease. More objective criteria in defining normal ageing should be used by the investigators. Changes in the optical factors such as senile miosis and opacification of the ocular media cannot entirely account for the age-related declines in the visual abilities and there might be involvement of retina or central visual pathways in the older subjects.

Visual evoked potentials (VEPs) can be a productive research methodology for studying such age-related visual declines owing to its objective and sensitive nature.Theyprovide a measure of normal functioning of the visual system and also for assessing the changes during different stages of life.2 Each sensory system has its own time of maturation and senescence.Visual evoked potentials can serve as a window into the central nature of neural processing and the pattern of age-related signal transmission delays in the visual system can be measured. Visual evoked potentials represent electrophysiologic responses to visual stimulation. Patterned visual stimuli are the preferred stimuli in various clinical settings. PVEP (pattern visual evoked potential) testing detects minor visual pathway abnormality with much greater sensitivity and accuracy than unpatterned stimuli.3 Of the various VEP components described in normal subjects- the N75, P100, and N145, P100 is the most consistent and least variable peak and the most clinically useful measurements on the responses to monocular full-field stimulation are (1) the P100 latency and (2) amplitude (N75-P100) of the P100 component. Additional latency, duration, and amplitude are highly variable measures and generally add little to clinical interpretation. 3

Determining the standards of normality for the visual evoked potentials is necessary, owing to the profound ageing effects on the visual evoked potential values during clinical interpretation of the tests.Assessment of various neurological diseases by the test becomes more reliable if the ageing effects have been taken into account. The clinical utility is required to be considered in the light of these physiologic effects.Moreover, it has been suggested that visual evoked potential (VEP) results are difficult to transfer even if stimulating and recording conditions are similar, due to the poorly understood effects of variation in stimulus conditions, as compared to the somatosensory and auditory evoked potential values.4Furthermore, the recent trends in the increase in the older population emphasizes the importance of acquisition of the data for this proportion of population for better clinical evaluations of this group of subjects. The maturation and senescence of different sensory system reflects different patterns. Glimore R (1995) who studied the process of senescence in sensory system found that the latencies of visual evoked potentials prolong by 2-4 ms/decade after age 40 years. 5In a study by Allison T et al (1983),VEP P100 latency did not change between 20 and 59 years.4 Also, there are strong evidences for the fact that the gender differences in young adults characteristically reveal increased P100 latency in males while increased N75-P100 amplitude in females. 6, 7 The characteristic variations have also to be investigated and ascertained in the older groups. The present study hence, is an attempt to contribute to the researches and share our investigations and findings by performing an objective evaluation of the visual functions in the subjects with the older age-group by way of pattern reversal visual evoked potentials (PRVEPs).

Materials and methods

The study was conducted on 120 healthy adults in the age group of 20-80 years(60 males and 60 females) with normal or corrected visual acuity. It was a cross-sectional analytical study. PRVEP was recorded in Electrophysiology laboratory in the department of Physiology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala. Approval from the institutional ethical committee was acquired to carry out the research work. A written informed consent was obtained. Subjects underwent complete neuro-ophthalmological examination after taking a detailed clinical history.

Inclusion criteria for the study were adult healthy subjects in the age group of 20-80 years with normal or corrected visual acuity, normal fundus and visual field examinations while exclusion criteria were subjects with metabolic, endocrine or demyelinating pathologies; glaucoma, optic neuropathies, inherited or acquired neurological disorders, compressive lesions of anterior visual pathways, HIV infections and history of cerebro-vascular accidents.

VEP testing was optimized byinstructing the subjects to come without the application of hair-oil or any hair chemical to the scalp and asked to wear their usual glasses or corrective lens. To prevent the effects of drowsiness on the VEP responses, they wereadvised to have an adequate sleep, the previous night. Before starting the procedure, they were explained about the test to ensure optimum cooperation. It was also ensured that no mydriatic or miotic drug 12 hours before the test was given to them. Application of electrodes was done after proper cleaning of the scalp skin.

VEP (visual evoked potential) was performed onAllengers Scorpio EMG, EP, NCS system in a specially equipped electro-diagnostic procedure room with dark and sound attenuated environment for the test. Subjects were seated comfortably about 95 cm away from a video-monitor with a 30 cm screen. The video-monitor presented a black and white checker-board pattern with a fixation spot in the center of the screen (mean luminance 50 candela/m2 and contrast 70%). The checks reversed alternately at the rate of 2 cycles/sec. The visual angles subtended by the checksand the screen were 54.6 min and 19 degrees respectively. The signals were amplified (gain 20,000) and filtered with a system band pass filter of 2-100 Hz. Number of epochs were 100. Standard disc surface electrodes were placed and the electrode placement was according to the International 10/20 system with active electrode placed at Oz, reference electrode at Fz and ground electrode at Fpz.3 Volunteers were instructed to focus on a small red square at the center of the screen of video-monitor. Monocular stimulation was performed. To validate the reproducibility of the waveform, two responses were recorded and superimposed. P100 latencydifference within 2.5 ms and N75-P100 amplitudewithin 15% difference in replicated responses was accepted.3Parameters for the study were P100 latency and N75-P100 amplitude. The data was expressed as mean ± S.D.

The subjects were classified into six different age-groups:  Group I (20-30 years), Group II (31-40 years), Group III (41-50 years), Group IV (51-60 years), Group V (61-70 years) and Group VI (71-80 years). The effect of age in different age groups onPRVEP P100 latency and N75-P100 amplitude inboth the eyes (total 120 subjects/240 eyes) was compared and analyzed using one way ANOVA and post hoc tests (Tukey multiple comparison tests). Correlations of age with PRVEP latency and N75-P100 amplitudewas obtained using Pearson correlation coefficient. The effect of gender was obtained by unpaired t test. Statistical analysis was done by using SPSS (Statistical package for social science) version 20.0 statistical software. The analysis was done at 5 % level of significance. 

Results

Mean age of the study group (with 60 males and 60 females) was 50.14±17.23 years. Demographic and anthropometric data for males and females revealed no statistically significant differences in mean ages for males (50.5± 17.1 years)and females (49.83 ± 17.5 years), while height (males: 170.4±6 cms, females: 158.5±7.01 cms), weight (males: 65.1±11.2 kgs, females: 55.8±8 kgs) and head sizes (measured from nasion to inion) (males: 34.29±0.8 and females: 32.63 ±1.1 cms) were statistically significantly different (P<0.05).

Mean P100 latency in ms (milliseconds) ±SD and N75-P100 amplitudes in µv (microvolts) ± SD for both right and left eyes were compared among the subjects in six different age-groups (Group I: 20-30 years, group II: 31-40 years, group III: 41-50 years, group IV: 51-60 years, group V: 61-70 years and group VI: 71-80 years)(table 1, figure 1 and 2). Mean P100 latency increased with age (both eyes) with statistically significant differences (P<0.01)(one way ANOVA). The statistical significance was found between group I and group IV, group I and V and group I and group VI. Similarly, mean P100 latency in group II and group III varied significantly from VI(post hoc tests) (table 1). The differences in mean N75-P100 amplitude (both eyes), did not show statistical significance with age (P=0.197 and P=0.15 for right and left eyes respectively) (table 1). Correlation studies for age and mean P100 latencies revealed a statistically significant positive correlation (p<0.0001) for right as well as left eyeswith age (table 2). Correlation studies for age and mean N75-P100 amplitudes revealed a negative correlationwith age,but with no statistical significance (p>0.05) (table 2).

Age-related changes in males and females were analyzed separately. The increase in mean P100 latency with age was significant (P<0.01) in both males and females for both right and left eyes and for mean of both the eyes(mean of right eye and left eye were not statistically significant) (table 3) (figure 3). In males, within the group comparisons revealed significance between group I and V and that with VI (both the eyes)(post hoc test) (table 3). In females, within the group comparison revealed significance between group I and VI, within group II and VI and within group III and VI (post hoc test) (table 3). Hence, in males, it was group V (61-70 years) in which significant aging changes became evident first as compared to the young adults (20-30 years) while in females,the same could be noticed in 71-80 years of age-group. Similar aging changes in males and females for mean N75-P100 amplitude variations could not be found (table 4).

The influence of gender was assessed by comparing the mean P100 latencies and N75-P100 amplitudes in males and females (figure 4). The comparison between males and females was performedin different age-groups and among total males and females as well.Mean P100 latency in both the eyes were found to be greater in males as compared to females with statistically significant difference (p<0.05) in majority of the age-groups (unpaired t test) (table 3). P<0.0001, when mean P100 latency was compared between total males (n=60) and total females (n=60) (table 3). On the other hand, mean N75-P100 amplitudes exhibited decreased values in males as compared to females in all the age-groups (P<0.05) and in total subjects as well (P<0.0001) (unpaired t test) (table 4).

Discussion

Rapidly increasing size of the older adult population worldwide,accentuates the need to extend and elaborate the researches on aging changes in the older adults. Visual declines are among the most common changes due to senescence. These age-related declines cannot solely be explained on the basis of the changes in various optical characteristics in the older subjects, but neural elements of the visual system and visual pathway affection can be important factors in the aged. Visual evoked potentials are objective measures investigating the functional integrity of the visual system and can provide important informations regarding the physiologic and pathologic changes in the visual system. The study hence, included healthy subjects in a wider age-group including the elderly subjects in an attempt to find the electrophysiologic pattern of variations with ageing by pattern reversal visual evoked potentials.

The study reveals age-related changes in PRVEP mean P100 latency with statistical significance (P<0.0001) for both right and left eyes. The increase in mean P100 latency with age was statistically significant after the fifth decade of life as compared to the young adults (20-30 years) (table 1) (figure 1). The findings comply with previous similar studies. 8-13In the present study, P100 latency increased at the rate of 0.82 to 1.8 ms per decade after the fifth decade. Stockard JJ et al (1979)reported anincrease of 2.5 ms per decade after fifth decade of life whileGlimore R et al (1995) reported a prolongation of 2-4 ms/decade afterthe ageof 40 years. 5, 8According toKuba M et al (2008), pattern-reversal VEPlatencies increased only 0.25 ms/year in healthy subjects with 19-83 years of age.12On the other hand, Allison T et al (1983) demonstrated no significant change in VEP P100 latency between 20 and 59 years. 4

Mean N75-P100 amplitude variations with age did not show statistical significance (P>0.05) (table 1). The findings conform to the study by Mitchell KW et al (1987) who studied the subjects in 40-80 years of age-group and could not find age changes in VEP amplitudes. 9Similarly,Tobimastu S et al (1993) studied the subjects (19-84 years) and reported no aging effects in P100 amplitudes.10 In a study by Wright CE et al (1985),the amplitudes were constant from the twenties onwards, showing no further consistent age changes.13

Correlation studies further supported the findings asmean P100 latencies showed statistically significant positive correlation with age (P<0.0001) and a negative correlation obtained for N75-P100 amplitude with age did not reveal a statistical significance (table 2).Aging effects in males as well as females studied separately also revealed significant increase in P100 latency in both the sexes (P<0.01). However, males appeared to age, a decade earlier (61-70 years of age) as compared to females (71-80 years) (table 3). Similar gender differences due to aging were also reported by Allison T et al (1984)with greater aging changes in males. 11

The age-related delay in the central conduction timeobtained in the form of P100 latency prolongation with agingin the present study can be attributed to visual declines due to aging.2,11,14Neuronal loss, changes in cell membrane composition and senile plaques present in older subjectshave been speculated. Reduction in retinal illuminance due to the decrease in pupillary diameter with age has also been suggested. 13, 15Few other age-related changes documented in the neural elements of the aging visual system such as age-related loss of rods and cones,reduction in the number of cells in the primary visual cortex to about 25 % at the age of 60 and atrophy of the retinal ganglion cellscan also be involved in the electrophysiologic alteration in the visual pathways. 16-18

In the present study, gender comparison among the subjects reveals that the males have increased latency as compared to females in majority of the age-groups (table 3). The finding is in agreement with manystudies in the past.14,19,20The difference in the head sizes of males and females has been accounted for the differences in the P100 latency.6,7,20N75-P100 amplitude, however exhibited increase in females as compared to males in the present study when compared between total males and females and also when compared in different age-groups (table 4). This characteristic increase in amplitude in females is a relatively more consistent finding as compared to latency variation in gender and is supported by a number of studies in the past. 7,9,14,21Hormonal differences have been suggested to play role in theamplitude increase in females as compared to males.22 Anthropometric differences in males and females have little role to play in the same.Genetically determined sex differences in neuro-endocrinological systems and factors specific to CNS (central nervous system) processing of visual stimuli rather than global CNS anatomic or physiological factors have been suggested as the possible explanation for the amplitude change in the gender.23

Conclusion

Aging documents increase in PRVEP P100 latency with significant influence after the fifth decade of life. Effects on P100 latency are stronger in comparison with N75-P100 amplitude changes. Males demonstrate significant alterations in P100 latency earlier in life than females. The results of gender comparison in the form of increased P100 latency in males and increased N75-P100 amplitude in females, which arerelatively consistent findingsin young adults, are also the characteristic features in the elderly subjects. Pattern reversal visual evoked potentials are useful objective investigations to acquire evidences for electrophysiologic variations in the elderly individuals.

Acknowledgement

Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

The authors also thank Dr. Surjit Singh, Professor, Department of Physiology and Dr.V.V. Gopichand, Principal, MMIMSR, Mullana, Ambala for their encouragement and moral support.

Source of funding- Nil

Conflicts of interest- Nil

References:

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4. Allison T, Wood CC, Goff WR. Brain stem auditory, pattern-reversal visual, and short-latency somatosensory evoked potentials: latencies in relation to age, sex, and brain and body size. ElectroencephalogrClinNeurophysiol. 1983 Jun;55(6):619-36.

5. Gilmore R. Evoked potentials in the elderly. J ClinNeurophysiol. 1995 Mar;12(2):132-8.

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14. Emmerson-Hanover R, Shearer DE, Creel DJ, Dustman RE. Pattern reversal evoked potentials: Gender differences and age-related changes in amplitude and latency. ElectroencephalogrClinNeurophysiol 1994; 92:93-101.

15. WealeRA . Retinal illumination and age. Transactions of the Illuminating Engineering Society 1961; 26: 95-100.

16. Marshall J, Grindell J, Ansell PL and Borwein B. Convolution in human rods: An aging process. British Journal of Ophthalmology 1980; 63: 181-87.

17. Kuwabara T. Age related changes in the eye. In: Han SS and Coons DH, eds. Special senses in aging. Ann Arbor, Institute of Gerontology: University of Michigan, 1979: 47-78.

18. Devaney KO and Johnson HA 1980 Neuron loss in the aging visual cortex of man Journal of Gerontology 1980; 35: 836-841.

19. Fenwick PB, Brown D, Hennesey J. The visual evoked response to pattern reversal in 'normal' 6-11-year-old children. ElectroencephalogrClinNeurophysiol. 1981Jan; 51(1):49-62.

20. Guthkelch AN, Bursick D, Sclabassi RJ: The relationship of the latency of the visual P100 wave to gender and head size. ElectroencephalogrClinNeurophysiol 1987; 68: 219-222.

21. Gupta S, Gupta G, Deshpande VK. Visual evoked potentials: Impact of age, gender, head size and BMI. International Journal of Biomedical and Advance Research 2016;7(1): 22- 26.

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A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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