International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 05 Issue 20, October, 2013

Pages: 94-100

Date of Publication: 02-Nov-2013

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Author: Gopal Sharma, Deepa Das, Reema Rao, Sameer Zope

Category: Healthcare

Abstract:The ameloblastoma is a true neoplasm of odontogenic epithelium which has been described as persistent, locally invasive tumor having aggressive but benign growth characteristics. Several clinico-radiological and histological types are included in the ameloblastoma. Apart from the most commonly encountered clinico - pathologic models there are few variants, whose biological profile is unknown or not elicited. Unicystic ameloblastoma (UCA) is one of the types which refers to those cystic lesions that show clinical, radiographic, or gross features of a mandibular cyst, but on histological examination show a typical ameloblastous epithelium lining part of the cystic cavity, with or without luminal and/or mural tumor growth. Here we report a case of UA in a 40-year-old male with detailed clinical, radiographical and histopathological features with differential diagnosis and treatment.

Keywords: Multilocular appearance, Non- dentigerous variant, Mural, Unicystic ameloblastoma.

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Many benign lesions cause mandibular swellings, whose origin can be, attributed to odontogenic or non-odontogenic causes. The most commonly encountered are ameloblastomas, radicular cysts, dentigerous cysts, odontogenic keratocysts, central giant cell granulomas, fibro-osseous lesions and osteomas.(1) The most common tumor of odontogenic origin is ameloblastoma, which develops from epithelial cellular elements and dental tissues in their various phases of development.(2) The term ameloblastoma was coined by Churchill in 1934. It represents 1% of all oral odontogenic epithelial tumors and 18% of all odontogenic tumors.(3)

As per the WHO system of 2003, ameloblastoma is classified based on differences in biologic behavior, treatment plan and recurrence rate as follows: classic solid / multicystic ameloblastoma, unicystic ameloblastoma, peripheral ameloblastoma, and desmoplastic ameloblastoma, including the so-called hybrid lesions.(3)

Solid or multicystic variants of ameloblastomas are locally aggressive, and recur if inadequately excised. However, unicystic ameloblastoma was identified as a prognostically distinct entity with less aggressive behavior.(4)

More than 80% of all ameloblastomas are solid or multicystic variants, with unicystic ameloblastoma being an important clinicopathologic form of ameloblastoma and occupying the remaining 20% of the cases along with peripheral ameloblastoma. Peripheral tumors are odontogenic tumors, with the histological characteristics of intraosseous ameloblastoma that occur solely in the soft tissues covering the tooth-bearing parts of the jaws. Unicystic tumors include those that have been variously referred to as mural ameloblastomas, luminal ameloblastomas, and ameloblastomas arising in dentigerous cysts (DCs).(2) It is a less aggressive variant and it has a low rate of recurrence, although lesions showing mural invasion are an exception and should be treated more aggressively.(5)

Here we are presenting a case of UCA in a 40-year-old male in left body of the mandible.


A 40 year old male had reported to the Department of Oral Medicine, Diagnosis, and Radiology, Y.M.T Dental college and Hospital, Kharghar, Navi Mumbai, Maharashtra, India with a chief complaint of swelling on left side of the face since 4 months. History revealed that the swelling was gradual in onset and slowly increased to the present size with mild, intermittent pain. Swelling was not associated with fever, malaise or any other symptoms. No history of paraesthesia, weight loss or loss of appetite was reported.

Past dental history of the patient revealed surgical extraction of a tooth in lower left side of the jaw 10 years back. Medical, social and family history were not contributory.  On general examination, he was moderately built and nourished with normal vital signs.

Clinical examination

A solitary swelling was seen over left side of the face of about 6x4cm size extending antero-posteriorly from symphysis menti to the angle of mandible and supero-inferiorly from corner of the lip to about 1cm below the lower border of mandible. The skin over the swelling was normal without any change in the colour.  On palpation, temperature over the swelling was not raised. The swelling was hard in consistency and slightly tender. Single left submandibular lymph node was palpable, about 2x2 cm in size, firm, mobile and slightly tender. (Figure 1)

Intra oral examination revealed a solitary swelling of about 5x2 cm size on lower left buccal vestibule extending antero-posteriorly from mesial of 34 to distal of 38 and obliterating the buccal vestibule in relation with 34, 35, 37, 38 and the edentulous area of 36 with maximum dimension in 36 region. Lingually, the swelling extended in relation with 34, 35, 37, 38 and the edentulous area of 36. The mucosa over the swelling appeared smooth and normal with no sinus tract or any discharge. On palpation, the swelling was bony hard in consistency and tender with fluctuancy elicited in the 36 region.

The teeth in the affected area were immobile and non tender to percussion. 36 was missing, and37 had proximal caries and occlusal facet.(Figure 2)

A provisional diagnosis of benign odontogenic tumor was given on the basis of age and sex of the patient, site, consistency of the swelling and cortical expansion.

The patient was then subjected to following investigations. A complete hemogram was advised which showed all the values to be in the normal range. Electric pulp vitality testing was done for 31, 32, 33, 34, 35, 37 and 38 which revealed all the teeth to be vital. Intra oral periapical radiograph of 36 region shows missing 36 and well defined multilocular radiolucency in the apical region of 33, 34, 35, and 37 along with root resorption. Lateral mandibular occlusal radiograph revealed a multilocular radiolucency extending from the distal aspect of 32 to the distal aspect of 38 with Buccal and lingual cortical expansion. Orthopantamograph (OPG) revealed a large well-defined multilocular radiolucency on the left body of the mandible, extending antero-posteriorly from the mesial of 31 to the  mesial of 38; supero-inferiorly from the alveolar crest region to the lower border of mandible. The internal aspect of the lesion is multilocular with large size locules separated by radiopaque septae giving it as typical soap bubble appearance. The lesion is causing resorption of the roots of 33, 34, 35, and 37 and displacement of the inferior alveolar nerve downwards. The inferior border of the mandible is intact. (Figure 3)

Cone beam computed tomography revealed  expansile lesion on the posterior aspect of  left side of the mandible, extending antero-posteriorly from the distal of 31 to the distal of 38; supero-inferiorly from the alveolar crest region to the lower border of mandible. The margins of the lesion are well defined. The internal aspect of the lesion is multilocular separated by few septae. Expansion, thinning and discontinuity of the buccal and lingual cortical plates is noted. Thinning and discontinuity of the lower border of mandible is noted along the lingual aspect of 37 and 38 region (Figure 4). The lesion was then aspirated; a thin straw color fluid was obtained from the lesion, which was then sent for the pathological evaluation.  The report of it stated as mixed inflammatory lesion.

The differential diagnosis included ameloblastoma,   odontogenic keratocyst (OKC), central giant cell granuloma (CGCG), and odontogenic myxoma. Bone biopsy was done. The sample was then sent for the histopathological analysis and a diagnosis of unicystic ameloblastoma is obtained.

En bloc resection of the mandible from  mesial of 42 to the distal of 38 was done with peripheral osteotomy sparing the lower border of the mandible. Reconstruction surgery was advised. The post operative specimen measured about 4x5 cm approximately.(Figure 5) The post operative specimen was also subjected for the histopathological analysis and a confirmed diagnosis of unicystic ameloblastoma with mural proliferation was obtained. Post operative OPG after 3 weeks was taken. (Figure 6)             


Unicystic ameloblastoma, a variant of ameloblastoma, was first described by Robinson and Martinez in 1977. Unicystic ameloblastoma (UCA) is a rare type of ameloblastoma, accounting for about 5-10% of intraosseous ameloblastomas.(6-8) It usually occurs in the second and third decades of life. More than 90% are located in the mandible in the posterior region, followed by the parasymphysis region, the anterior maxilla, and the posterior maxilla(3).

UCA is usually asymptomatic, although a large tumor may cause painless swelling of the jaws with facial asymmetry. This swelling is the result of an expansion of the cortical plates of the jaw and can be identified by palpation as hard and bony.(10) In  our  case study, patient exhibits slightly tender swelling. The clinical and radiographic findings in most cases of unicystic ameloblastoma suggest that the lesion is an odontogenic cyst, particularly dentigerous cyst. However, few are not associated with impacted teeth which are called non-dentigerous variant. Most of the UCAs are associated with an impacted tooth, the mandibular third molar being involved most often.(1)

The ratio of the maxilla: Mandible is 1:7 for the dentigerous variant, versus 1:4.7 for the non-dentigerous type.(11)  Gender distribution shows a slight male predilection with a male: female ratio of 1.6:1 for dentigerous variant. However, when the tumor is not associated with an unerupted tooth, the gender ratio is reversed to a male to female ratio of 1:1.8.(1)  In our case, the patient was a male, and the lesion was on the left body of the mandible and a non-dentigerous type.

The pathogenesis of cystic ameloblastomas remains obscure.  There have been many debates regarding whether unicystic ameloblastoma develops de novo or arises in an existing cyst. Leider et al, proposed three pathogenic mechanisms for the evolution of Unicystic ameloblastoma: reduced enamel epithelium, from dentigerous cyst and due to cystic degeneration of solid ameloblastoma.(3)

The 2 main radiographic appearance of UCAs has been divided into : unilocular and multilocular, and these have clear preponderance for the unilocular pattern.(5) This preponderance is predominantly marked for the dentigerous variant, where the unilocular to multilocular ratio is 4.3 : 1, and for the nondentigerous type, this ratio is 1.1 : 1 (7). In UCA, involved teeth show varying degrees of root resorption.(12 ) Eversole et al., identified predominant radiographical patterns for UCA: Unilocular, scalloped, macromultilocular, pericoronal, interradicular, or periapical expansile radiolucencies.(11) In this case, the patient was a 40 year old, male and the lesion on radiographs shows multilocular appearance which was not associated with impacted teeth and hence, non-dentigerous type. This makes this case a unique report in the literature of UCA.

The present case was differentiated from other multilocular lesions like solid ameloblastoma, central giant cell granuloma, odontogenic myxoma, and cystic lesions like odontogenic keratocyst (OKC), dentigerous cyst (DC), and residual cyst. Based on fluctuant nature from which gave a positive aspirate, the multilocular lesions like solid ameloblastoma, central giant cell granuloma, odontogenic myxoma was ruled out. OKC produces thick cheesy material instead of thin straw color fluid which is seen in this case. DC is ruled out as there was no impacted tooth present. Residual cyst will not produce so much of expansion as seen in this case.

The early ameloblastic changes within the cyst wall were first described by Vickers and Gorlin in 1970, and their histological criteria for the diagnosis of unicystic ameloblastoma includes a cyst lined by ameloblastic epithelium with a tall columnar basal layer, sub nuclear vacuoles, reverse polarity of hyper chromatic nucleus, and a thin layer of oedematous, degenerating stellate reticulum-like cells on the surface.(13) The mural extension into the cystic wall is the frequently seen feature, and the term mural UCA is used when the thickened lining (either plexiform or follicular) penetrates the adjacent capsular tissue.(12)

In a clinicopathologic study of 57 cases of unicystic ameloblastoma, Ackermann classified this entity into the following three histological groups:  (14)

Group I— luminal (tumor confined to the luminal surface of the cyst);

 Group II— intraluminal/plexiform (nodular proliferation into the lumen without infiltration of tumor cells into the connective tissue wall);

 Group III— mural  (invasive islands of ameloblastomatous epithelium in the connective tissue wall not involving the entire epithelium).

Another histologic subgrouping by Philipsen and Reichart has also been described as: (7)

Subgroup 1— luminal; 

Subgroup 1.2— luminal and intraluminal;

Subgroup 1.2.3— luminal, intraluminal and intramural; 

Subgroup 1.3— luminal and intramural.

The mural variety is seen to be more often associated with the ‘nondentigerous’ type of these lesions, while the intraluminal proliferations are more than twice as frequent in UCAs of the ‘dentigerous’ type.(15)

A definitive diagnosis of unicystic ameloblastoma can only be done by histological examination of the entire lesion and cannot be predicted preoperatively on clinical or radiographic grounds. The epithelial lining of a UCA is not always uniformly characteristic and is often lined partly by a nonspecific thin epithelium that mimics the dentigerous cyst lining. Thus, true nature of the lesion becomes evident only after enucleation when the entire specimen is available for microscopy.(15)

Treatment planning depends on the histological type of UCA. The UCA which is diagnosed as  subgroups 1 and 1.2 may be treated conservatively (careful enucleation), whereas Subgroups 1.2.3 and 1.3 should be treated aggressively.(3) As UCA tends to affect young adolescent patients, the concern to minimize surgical trauma and permit jaw function and tooth development to proceed reasonably unimpaired.(15) According to Ackermann et al. classification, this case belongs to Type 3 and the excised specimen was also subjected to histopathological analysis, which confirmed the diagnosis of UCA with mural proliferations.

Whatever surgical approach the surgeon decides to take, long-term follow-up is mandatory as recurrence of unicystic ameloblastoma may be long delayed. However, recent emerging clinical evidence have indicated the aggressive nature of the so-called unicystic ameloblastoma.(17) Lau and Samman reported recurrence rates of 3.6% for resection, 30.5% for enucleation alone, 16% for enucleation followed by Carnoy’s solution application, and 18% by marsupialisation followed by enucleation for UCA.(16)


Ameloblastoma is a tumor with a strong propensity of recurrence, especially when the ameloblastic focus penetrates the adjacent tissue from the wall of the cyst. Radiographically, most of ameloblastoma show multilocularity, whereas unicystic ameloblastoma show a single large unilocular radiolucency. Very rarely, we come across a case with presentation of multilocular, non dentigerous variant and unicystic type in the male patient. Unicystic variant of ameloblastoma with aggressive histological behaviour also might be successfully treated with marsupialisation with subsequent enucleation, and this approach should be considered as an alternative to resection.


  1. Ammanagi R, Keluskar V, Issrani R. Plexiform unicystic ameloblastoma: Report of a case with unusual presentation. Int J Dent Case Reports. 2011; 1: 1–10.
  2. Ramesh RS, Manjunath S, Ustad TH, Pais S, Shivakumar K. Unicystic ameloblastoma of the mandible: An unusual case report and review of literature. Head Neck Oncol. 2010; 2: 1–5.
  3. V. Nagalaxmi, Mithare Sangmesh, Kotya Naik Maloth, Srikanth Kodangal,Vani Chappidi, and Stuti Goyal, Unicystic Mural Ameloblastoma: An Unusual Case Report, Hindawi Publishing Corporation Case Reports in Dentistry; Volume 2013.
  4. Robinson L, Martinez MG. Unicystic ameloblastoma: a prognostically distinct entity. Cancer 1977; 40: 2278–85.
  5. Gümgüm S, Ho?gören B. Clinical and radiologic behaviour of ameloblastoma in 4 cases. J Can Dent Assoc. 2005; 71: 481–4.
  6. Reichart PA, Philipsen HP.. Odontogenic tumours and allied lesions. Quintessence Publishing Co UK. 2004: 41-77.
  7. Leider AS, Eversole LR, Barkin ME. Cystic ameloblastoma: A clinicopathological analysis. Oral Surg Oral Med Oral Pathol 1985; 60: 624-30.
  8. Gardner DG, Corio RL. Plexiform unicystic ameloblastoma: Variant of ameloblastoma with a low recurrence rate afer enucleation. Cancer 1984; 53: 1730-5.
  9. Lakshmi Kavitha Nadendla, Unusual imaging appearance of unicystic ameloblastoma. Contemp Clin Dent. 2012 Oct-Dec; 3(4): 475–477.
  10. Yunus M, Baig N, Haque AU, Aslam A, Atique S, Bostan S, et al. Unicystic ameloblastoma: A distinct clinicopathological entity. Pakistan Oral and Dent J. 2009; 29: 9–12.
  11. Rastogi S, Nijhawan S, Modi M, Kumar A, Aslam N, Latheef F. A large mixed radiolucent – Radioopaque lesion in the mandible: A nobel diagnostic approach. J Clin Diagn Res. 2010; 4: 2300–7.
  12. Philipsen, H. P. and Reichart, P. A. Unicystic ameloblastoma. A review of 193 cases from the literature. Oral Oncol. 1998; 34(5): 317-25.
  13. Braunshtein, E.; Vered, M.; Taicher, S. and Buchner, A. Clear cell odontogenic carcinoma and clear cell ameloblastoma: a single clinicopathologic entity? A new case and comparative analysis of the literature. J. Oral Maxillofac. Surg. 2003; 61(9): 1004-10.
  14. Ackermann, G. L.; Altini, M. and Shear, M. The unicystic ameloblastoma: a clinicopathological study of 57 cases. J. Oral Pathol. 1998; 17(9-10): 541-6.
  15. Kiran Kumar, K. R.; Giju Baby George; Sheeba Padiyath and Rupak, S. Mural Unicystic Ameloblastoma Crossing the Midline: A Rare Case Report. Int. J. Odontostomat. 2012; 6(1): 97-103.
  16. Lau SL, Samman N. Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review. Int J Oral Maxillofac Surg. 2006; 35: 681–90.
  17. Li TJ, Kitano M, Arimura K, Sugihara K. Recurrence of unicystic ameloblatoma: A case report and review of the literature. Arch Pathol Lab Med. 1998; 122: 371–4. 


Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to for more details.

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A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
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A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
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A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Leow Jun Xian and Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
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A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma COLAKOGLU entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by Arpita M. et al entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09
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List of Awardees

A Study by Ese Anibor et al. entitled "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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